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1
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究,得克萨斯大学西南医学中心(UT Southwestern)自噬研究中心的主任Beth Levine和团队已经明确:细胞自噬可以延长寿命、改善健康。他们以小鼠为模型发现,自噬水平提高的小鼠寿命更长、更健康。“具体来说,它们的寿命延长了约10%,且不太可能发生与年龄相关的自发性癌症、心脏病等疾病。”Beth Levine表示道。细胞自噬自噬是一种保护机制。当细胞内出现衰老的蛋白质、损坏的细胞器等废弃物时,自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用,从而确保细胞本身的代谢需求和某些细胞器的更新。细胞自噬过程(图片来源:华威大学)20年前,Beth Levine和同事发现了自噬生物学过程中的一个关键基因beclin 1。他们还发现,自噬对于健康而言必不可少,例如预防神经衰退性疾病、对抗癌症和感染。2003年,Beth Levine团队证实,自噬关联的基因机制对于长寿突变线虫(long-lived mutant roundworms)的寿命延长至关重要。“从那以后,关于‘自噬是延长寿命的关键机制’的观点尤为火热。” Beth Levine解释道,“随着年龄增长,细胞的自噬能力会下降,这可能会导致衰老。”自噬延长寿命然而,一个关键问题仍然没有得到解答:增强自噬水平是否有益于哺乳动物的健康?换句...
2
2019 - 05 - 06
来源: 中国科学报年初,一部电视剧《都挺好》火遍全国,大结局时剧中一直让人恨得牙痒痒的 “作爹” 苏大强,因患上了阿尔茨海默氏症(AD,俗称老年痴呆症)而成功“洗白”,惹出了不少人的眼泪。阿尔茨海默氏症离我们并不遥远,由它引发的故事也是常有耳闻,大多伴随着无奈与辛酸。随着全球老龄化进程的加快,愈来愈多的阿尔茨海默氏症患者将给家属及社会带来沉重的负担。根据国际阿尔茨海默氏病协会的统计数据,2018 年全世界有 5000 万老人患有痴呆,每 3 秒钟,就有 1 位患者产生;中国是阿尔茨海默氏病的重灾区,估计有 1000 万患者。关于阿尔茨海默氏症发病机制和治疗方法的研究一直都是科研界关注的重点之一。近日,中国科学院昆明动物研究所姚永刚课题组在阿尔茨海默氏症的治疗研究上取得重要进展,该研究阐明了核受体过氧化物酶体α激动剂吉非罗齐和匹立尼酸的抗阿尔茨海默氏症分子机制。相关论文在线发表于《自噬》(Autophagy)杂志上。诱导自噬,清除 Aβ作为发生在老年前期与老年期的一种常见的神经退行性脑病,阿尔茨海默氏症是最常见的老年痴呆类型,其发病率随着年龄增长而显著增加。其临床表现为病人渐进性记忆丧失、认知能力下降并伴有焦虑等其他精神相关症状。对于阿尔茨海默氏症的发病机制,现有很多学说,其中影响最广泛的有β- 淀粉样蛋白(β-amyloid,Aβ)瀑布理论,认为 Aβ的生成与清除失衡是导致神经元变...
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2019 - 09 - 05
2016年《消失的微生物》一书问世,肠道微生态研究走入大众视野,目前全球范围内针对微生物与肥胖、哮喘、过敏、糖尿病、肿瘤、精神类疾病的研究正逐步开展。一、肠道微生物概况人体是由自身细胞及共生的大量微生物细胞所共同组成的复杂共生生命体。目前研究认为人体肠道内聚集的微生物数目可达1012~1014个,是人体自身细胞数目的10倍,微生物包含的基因数目超过987万个,人类自身基因数只有2万个左右,是人体自身基因数目的几百倍,这些后天获得的共生菌群及其所携带的遗传及分子信息即可称为微生物组。(一)人体肠道微生物是如何建立的?有研究表明,人体在出生成长过程中,主要在两个重要的环节、以两种不同的方式实现对肠道菌群的塑造。第一个环节是在分娩过程,婴儿会从母亲产道获得健康的肠道菌群,剖腹产和孕期抗生素则会改变正常婴儿菌群的建立。另一个环节则是出生后的哺乳及断奶后的膳食干预。在女性乳腺中存在着乳酸菌等系列微生物,这些微生物在哺乳过程中进入并定植于婴儿肠道。随着哺乳期的结束,日趋丰富的膳食外源营养物质则长期调节着人体肠道微生物中的的变化。(二)肠道微生物对人体健康有何影响?肠道菌群与人体互利共生,依靠人体没有消化的食物残渣和肠道分泌的黏液和脱落的死细胞作为营养来维持很高的种群水平。活跃生长的肠道菌群会产生大量的活性物质,同时包括短链脂肪酸、维生素和抗氧化等有益健康的产物,以及神经毒素、致癌物质和免疫毒素...
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时间: 2019 - 04 - 22
描述The LIVE/DEAD™ Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.• Stable—dyes are freeze dried in separate vials to maintain stability• Robust—staining pattern is the same before and after fixation• Bright signal—allows...
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时间: 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
型号:
时间: 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.•  Impermeant to live cells•  Excitation/Emission: 504/523 nm•  Use with 488 Argon-ion laser•  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
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时间: 2019 - 04 - 18
描述Premo™ FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo™ FUCCI Cell Cycle Sensor is delivered by high...
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时间: 2019 - 04 - 18
描述CountBright™ absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright™ absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright™ beads are mixed in the test sample, absolut...
型号:
时间: 2019 - 04 - 17
描述CellTrace™ CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.• Superior performance—bright, single-peak staining enables visualization of multiple generations• Long-term signal stability—well-retained in cells for several days post stain• Non-toxic—staining does not adversely effect cell health• Simple, robust staining protocolView a selection guide for all CellTrace™ Cell Proliferation Kits fo...
型号:
时间: 2019 - 04 - 17
描述CellTrace™ CFSE 细胞增殖试剂盒 (CellTrace™ CFSE Cell Proliferation Kit) 以方便的一次性瓶装形式提供用途广泛,稳定性高的细胞示踪剂。 羧基荧光素二醋酸盐琥珀酰亚胺酯,常称为 CFSE,可被动扩散进入细胞。 这种试剂没有颜色和荧光,直至细胞内的酯酶去除其醋酸盐基团,产生能发出明亮荧光的羧基荧光素琥珀酰亚胺酯。 琥珀酰亚胺酯与细胞内氨基反应,形成稳定且能用醛固定剂固定的荧光偶联物。 此试剂盒包含十份一次性瓶装的 CFSE,因此进行小规模实验时无需制备过量的易变质 CFSE 储存液。 此试剂盒还包括高质量的 DMSO(二甲基亚砜)和详细的实验方案。For Research Use Only. Not for use in diagnostic procedures.图表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
型号:
时间: 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue™ Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.• Accurate—superior results compared to BrdU assays• Fast—results in as little as 90 minutes• Economical—more assays per kitView selection guide for all Click-iT™ EdU and Click-iT™ Plus EdU assays for flow c...
型号:
时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
型号:
时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
型号:
时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
型号:
时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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