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酸奶对机体健康有什么好处？
酸奶对机体健康有什么好处？
2018 - 07 - 13
对于酸奶我们并不陌生，超市冷藏柜中形形色色的酸奶有时候常常让我们眼花缭乱，酸奶作为人们日常饮食中不可缺少的食物，其对机体健康都有什么好处呢？看看下面这些研究吧！【1】希腊酸奶vs原味酸奶vs低脂酸奶 你如何选择一种最健康的酸奶？新闻阅读：Plain， Greek， low-fat？ How to choose a healthy yoghurt酸奶是世界上最古老的发酵乳制品之一，其发源可以追溯到人类文明的开始，当人类开始驯养动物生产牛奶时，对于牛奶的保质期，人类就需要想出一些解决方案了。yoghurt（酸奶）一词来自土耳其，也就是说，在酸奶的生产过程中，牛奶会发生凝结或增稠的过程。与牛奶一样，酸奶也富含钙质和蛋白质，而且其还能为机体提供其它营养成分，比如碘、维生素D、B2、B12和锌等。但酸奶的营养要高于牛奶，主要的原因是发酵的过程会让其更易于被机体所消化，因此营养物质就可以很轻松地被机体所吸收。然而酸奶也有很多类型，比如希腊酸奶和液态酸奶，以及一些添加水果和益生菌的酸奶，那么你知道哪种酸奶最健康吗？通过向鲜奶中引入一些特定的细菌就能制作酸奶了，比如嗜热链球菌、德氏乳杆菌和保加利亚乳杆菌等。通常情况下这些细菌都会在酸奶中出现并且形成酸奶发酵液，它们的协同关系是最终产品一致性的关键因素，同时这也能够带来一些健康益处，比如降低机体腹泻的严重程度和持续时间等。【2】J Nutr and ...
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抗高血脂药物诱导自噬为治疗 AD 带来新思路
抗高血脂药物诱导自噬为治疗 AD 带来新思路
2019 - 05 - 06
来源： 中国科学报年初，一部电视剧《都挺好》火遍全国，大结局时剧中一直让人恨得牙痒痒的 “作爹” 苏大强，因患上了阿尔茨海默氏症（AD，俗称老年痴呆症）而成功“洗白”，惹出了不少人的眼泪。阿尔茨海默氏症离我们并不遥远，由它引发的故事也是常有耳闻，大多伴随着无奈与辛酸。随着全球老龄化进程的加快，愈来愈多的阿尔茨海默氏症患者将给家属及社会带来沉重的负担。根据国际阿尔茨海默氏病协会的统计数据，2018 年全世界有 5000 万老人患有痴呆，每 3 秒钟，就有 1 位患者产生；中国是阿尔茨海默氏病的重灾区，估计有 1000 万患者。关于阿尔茨海默氏症发病机制和治疗方法的研究一直都是科研界关注的重点之一。近日，中国科学院昆明动物研究所姚永刚课题组在阿尔茨海默氏症的治疗研究上取得重要进展，该研究阐明了核受体过氧化物酶体α激动剂吉非罗齐和匹立尼酸的抗阿尔茨海默氏症分子机制。相关论文在线发表于《自噬》（Autophagy）杂志上。诱导自噬，清除 Aβ作为发生在老年前期与老年期的一种常见的神经退行性脑病，阿尔茨海默氏症是最常见的老年痴呆类型，其发病率随着年龄增长而显著增加。其临床表现为病人渐进性记忆丧失、认知能力下降并伴有焦虑等其他精神相关症状。对于阿尔茨海默氏症的发病机制，现有很多学说，其中影响最广泛的有β- 淀粉样蛋白（β-amyloid，Aβ）瀑布理论，认为 Aβ的生成与清除失衡是导致神经元变...
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Nature：挑战常规！揭示一些乳腺癌和卵巢癌对PARP抑制剂产生耐药性的新机制
Nature：挑战常规！揭示一些乳腺癌和卵巢癌对PARP抑制剂产生耐药性的新机制
2018 - 07 - 20
一种非常复杂的治疗一些乳腺癌和卵巢癌的方法就是使用一类叫做PARP抑制剂的药物。PARP抑制剂旨在利用让发生某些突变的肿瘤特别致命的缺陷。然而，这种靶向癌症治疗方法有时会失败，科学家们迫切地想要知道其中的原因。 如今，在一项新的研究中，美国洛克菲勒大学的Titia de Lange教授及其团队对这种耐药性机制提供了新的认识，并且为抵抗这种耐药性提供了新的希望。他们发现了由基因BRCA1发生的错误引发的一些癌症逃避旨在杀死它们的定制药物的分子机制。这一发现也挑战了之前针对这些PARP抑制剂成功地或未能给患者带来益处的机制作出的猜测。相关研究结果于2018年7月18日在线发表在Nature期刊上，论文标题为“53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in”。图片来自Laboratory of Cell Biology and Genetics at The Rockefeller University。他们的发现有助于解释为什么某些癌症会对PARP抑制剂作出反应，而其他癌症却没有---这种认识最终可能有助于改善对患者的治疗。 缺陷和机会 专家们预测今年将有大约288000例乳腺癌和卵巢癌新确诊病例。这些癌症的很大一部分是由人类基因组中的两个最臭名昭着的基因--- ...
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LIVE/DEAD™ Fixable Green Dead Cell Stain Kit, for 488 nm excitation
产品名称： LIVE/DEAD™ Fixable Green Dead Cell Stain Kit, for 488 nm excitation
型号：
时间： 2019 - 04 - 22
描述The LIVE/DEAD™ Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.• Stable—dyes are freeze dried in separate vials to maintain stability• Robust—staining pattern is the same before and after fixation• Bright signal—allows...
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Dead Cell Apoptosis Kit with Annexin V FITC and PI, for flow cytometry
产品名称： Dead Cell Apoptosis Kit with Annexin V FITC and PI, for flow cytometry
型号：
时间： 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
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SYTOX™ Green Nucleic Acid Stain - 5 mM Solution in DMSO
产品名称： SYTOX™ Green Nucleic Acid Stain - 5 mM Solution in DMSO
型号：
时间： 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.•  Impermeant to live cells•  Excitation/Emission: 504/523 nm•  Use with 488 Argon-ion laser•  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
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Premo™ FUCCI Cell Cycle Sensor (BacMam 2.0)
产品名称： Premo™ FUCCI Cell Cycle Sensor (BacMam 2.0)
型号：
时间： 2019 - 04 - 18
描述Premo™ FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo™ FUCCI Cell Cycle Sensor is delivered by high...
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CountBright™ Absolute Counting Beads, for flow cytometry
产品名称： CountBright™ Absolute Counting Beads, for flow cytometry
型号：
时间： 2019 - 04 - 18
描述CountBright™ absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright™ absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright™ beads are mixed in the test sample, absolut...
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CellTrace™ CFSE Cell Proliferation Kit, for flow cytometry
产品名称： CellTrace™ CFSE Cell Proliferation Kit, for flow cytometry
型号：
时间： 2019 - 04 - 17
描述CellTrace™ CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.• Superior performance—bright, single-peak staining enables visualization of multiple generations• Long-term signal stability—well-retained in cells for several days post stain• Non-toxic—staining does not adversely effect cell health• Simple, robust staining protocolView a selection guide for all CellTrace™ Cell Proliferation Kits fo...
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CellTrace™ CFSE Cell Proliferation Kit - For Flow Cytometry
产品名称： CellTrace™ CFSE Cell Proliferation Kit - For Flow Cytometry
型号：
时间： 2019 - 04 - 17
描述CellTrace™ CFSE 细胞增殖试剂盒 (CellTrace™ CFSE Cell Proliferation Kit) 以方便的一次性瓶装形式提供用途广泛，稳定性高的细胞示踪剂。 羧基荧光素二醋酸盐琥珀酰亚胺酯，常称为 CFSE，可被动扩散进入细胞。 这种试剂没有颜色和荧光，直至细胞内的酯酶去除其醋酸盐基团，产生能发出明亮荧光的羧基荧光素琥珀酰亚胺酯。 琥珀酰亚胺酯与细胞内氨基反应，形成稳定且能用醛固定剂固定的荧光偶联物。 此试剂盒包含十份一次性瓶装的 CFSE，因此进行小规模实验时无需制备过量的易变质 CFSE 储存液。 此试剂盒还包括高质量的 DMSO（二甲基亚砜）和详细的实验方案。For Research Use Only. Not for use in diagnostic procedures.图表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
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Click-iT™ EdU Pacific Blue™ Flow Cytometry Assay Kit
产品名称： Click-iT™ EdU Pacific Blue™ Flow Cytometry Assay Kit
型号：
时间： 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue™ Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.• Accurate—superior results compared to BrdU assays• Fast—results in as little as 90 minutes• Economical—more assays per kitView selection guide for all Click-iT™ EdU and Click-iT™ Plus EdU assays for flow c...
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Attune™ NxT Acoustic Focusing Cytometer, blue
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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