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1
2019 - 09 - 29
2019年8月24日讯 /生物谷BIOON /——一项新的研究表明,一种特殊的碳水化合物在调节人体血压方面发挥着重要作用。哥本哈根大学和Rigshospitalet的研究人员用老鼠做了一项新的研究证明了这一点。研究人员认为,这一发现可能对改进高血压药物具有巨大的潜力。高血压和低血压都可能对健康产生不良后果,分别导致心血管疾病和晕厥。现在,研究人员对有助于调节血压的因素有了更多的了解。这项新研究结果发表在《Journal of Biological Chemistry》杂志上。在哥本哈根大学和Rigshospitalet的跨学科合作中,博士生Lasse Holst Hansen在人类身上一种特殊的肽激素上发现了一种特定形式的碳水化合物或糖。此外,在对大鼠的实验中,研究小组发现含有这种糖的肽激素会影响血压的调节。他们希望,他们的研究结果在未来可以用于开发更好的高血压药物。图片来源:https://cn.bing.com'对于开发一种没有副作用(比如晕厥)的现代治疗高血压的方法,这可能是一个非常好的机会。人们早就知道这种肽激素对血压非常重要,但到目前为止还不能用于治疗。这一发现可能只是因为我们跨学科合作、基础和临床研究相结合的结果。'Rigshospitalet临床生物化学系Jens Peter G?tze教授说道。大约五分之一的丹麦人患有高血压。这会增加心血管疾病的风险,如冠状动脉血栓...
2
2019 - 06 - 18
和50年前相比,现在人们日常卡路里摄入更多,平均每天高出650大卡,相当于每天多吃了一顿有汉堡、薯条和可乐的套餐,约占男性和女性每日所需食物能量的1/4和1/3。这些多余的卡路里不仅体现在越来越多人圆滚的腰围上,根据澳大利亚国立大学(Australian National University,ANU)的专家提醒,更会对我们的大脑带来“毁灭性”的影响。ANU团队的最新研究显示,由于不健康生活方式,大脑功能衰退可能比我们想象得更早。研究结果近日发表在Frontiers in Neuroendocrinology。根据世界卫生组织的数据,全球约有39%的成人超重,13%的成人肥胖。作为超重和肥胖的常见健康后果之一,2型糖尿病在2030年将影响约10%的成人。众所周知,2型糖尿病与大脑健康受损、认知功能退化有关,神经损伤也是糖尿病的并发症之一。那么,在还没有出现高血糖等符合糖尿病诊断的症状时,神经退行性病变和认知障碍是否也已经处于病理过程中了?又与哪些导致血糖变化的因素有关?研究团队回顾了近200项相关的国际研究,结果表明,即便是非糖尿病人群,由于血糖偏高和肥胖而导致的神经病变也在非常早期就开始了,并且从那时起就开始影响大脑健康和认知功能。比如,一项涉及澳大利亚超过7000人的PATH研究显示,哪怕血糖值尚且在正常范围内,但血糖偏高的人群,大脑中海马和杏仁核普遍萎缩更多,4年内体积约缩小...
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2019 - 06 - 14
随着技术飞速发展、医学数据的持续扩增以及硬件设备的不断提升,人工智能和医疗的结合方式越来越多样化。目前AI在医疗领域中的落地的应用场景主要有医学影像、智能诊疗、智能导诊、智能语音、健康管理、病例分析、医院管理、新药研发和医疗机器人等,其中在医学影像中的应用最为广泛。一、影像医学发展现状医学影像是医生完成诊断的主要依据,通过对影像的分析和比较,从而完成有依据的诊断。但是在实际过程中,往往会存在以下问题:(1)影像学诊断人才资源紧缺。医疗机构普遍缺乏高水平的影像医师,在疾病诊断时往往会发生同病异影,异病同影等情况。(2)传统定性分析存在诊断误差。医生普遍擅长定性分析,很多微小的定量变化无法通过肉眼判断,很难做到定量分析。(3)医生阅片时间长。目前的影像呈现方式为数据和图像,而不是最有效的信息,很大程度上限制了医生的人工阅片速度。二、AI+医学影像助力疾病诊断通过引入人工智能可有效解决部分问题,目前人工智能在医学影像领域的应用方向主要以下几类:1. 影像设备的图像重建AI可以通过算法的图像映射技术,将采集的少量信号恢复出与全采样图像同样质量的图像,而且使用图像重建技术,可以由低剂量的CT和PET图像重建得到高剂量质量图像。这样在满足临床诊断需求的同时,还能够降低辐射的风险。2. 智能辅助诊断疾病(1)智能辅助诊断肺部疾病国内应用AI+CT影像最为成熟的领域在肺结节的识别上。AI能够有效识...
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时间: 2019 - 04 - 22
描述The LIVE/DEAD™ Fixable Green Dead Cell Stain Kit is used to determine the viability of cells prior to the fixation and permeabilization required for intracellular antibody staining or prior to elimination of biohazardous materials using formaldehyde fixation. This kit has been optimized and validated for use with a blue laser flow cytometer.• Stable—dyes are freeze dried in separate vials to maintain stability• Robust—staining pattern is the same before and after fixation• Bright signal—allows...
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时间: 2019 - 04 - 18
描述This product detects the externalization of phosphatidylserine in apoptotic cells using recombinant annexin V conjugated to green-fluorescent FITC dye and dead cells using propidium iodide (PI). Propidium iodide stains necrotic cells with red fluorescence. After treatment with both probes, apoptotic cells show green fluorescence, dead cells show red and green fluorescence, and live cells show little or no fluorescence.
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时间: 2019 - 04 - 18
描述SYTOX® Green nucleic acid stain is an excellent green-fluorescent nuclear and chromosome counterstain that is impermeant to live cells, making it a useful indicator of dead cells within a population.•  Impermeant to live cells•  Excitation/Emission: 504/523 nm•  Use with 488 Argon-ion laser•  Works with mammalian cells and both Gram-positive and Gram-negative bacteriaSimple Viability Determination SYTOX® Green allows quick determination of cell viability when usin...
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时间: 2019 - 04 - 18
描述Premo™ FUCCI Cell Cycle Sensor is a fluorescent, two-color sensor of cell cycle progression and division in live cells. It allows accurate and sensitive cell cycle analysis of individual cells or a population of cells by fluorescence microscopy, flow cytometry, or high-content imaging.At 2 x 200 µL, this is a smaller pack size version (1/5 volume) of the popular full-size product and perfect for testing its performance in your system.The Premo™ FUCCI Cell Cycle Sensor is delivered by high...
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时间: 2019 - 04 - 18
描述CountBright™ absolute counting beads are a calibrated suspension of microspheres that are brightly fluorescent across a wide range of excitation and emission wavelengths (UV to 635 nm excitation and 385-800 nm emission). CountBright™ absolute counting beads are mixed with the cell sample and assayed via flow cytometry. By comparing the ratio of bead events to cell events, absolute numbers of cells in the sample can be calculated. Because CountBright™ beads are mixed in the test sample, absolut...
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时间: 2019 - 04 - 17
描述CellTrace™ CFSE Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.• Superior performance—bright, single-peak staining enables visualization of multiple generations• Long-term signal stability—well-retained in cells for several days post stain• Non-toxic—staining does not adversely effect cell health• Simple, robust staining protocolView a selection guide for all CellTrace™ Cell Proliferation Kits fo...
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时间: 2019 - 04 - 17
描述CellTrace™ CFSE 细胞增殖试剂盒 (CellTrace™ CFSE Cell Proliferation Kit) 以方便的一次性瓶装形式提供用途广泛,稳定性高的细胞示踪剂。 羧基荧光素二醋酸盐琥珀酰亚胺酯,常称为 CFSE,可被动扩散进入细胞。 这种试剂没有颜色和荧光,直至细胞内的酯酶去除其醋酸盐基团,产生能发出明亮荧光的羧基荧光素琥珀酰亚胺酯。 琥珀酰亚胺酯与细胞内氨基反应,形成稳定且能用醛固定剂固定的荧光偶联物。 此试剂盒包含十份一次性瓶装的 CFSE,因此进行小规模实验时无需制备过量的易变质 CFSE 储存液。 此试剂盒还包括高质量的 DMSO(二甲基亚砜)和详细的实验方案。For Research Use Only. Not for use in diagnostic procedures.图表Suppressive capacity of isolated Treg cells.Suppressive capacity of isolated Treg cells. (A) CD4+ CD25–cells were stained with Ca...
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时间: 2019 - 04 - 17
描述The Click-iT® EdU Pacific Blue™ Flow Cytometry Assay Kit provides a simplified, more robust assay for analyzing DNA replication in proliferating cells as compared to traditional BrdU methods. Newly synthesized DNA is analyzed using the 405 nm laser of the flow cytometer.• Accurate—superior results compared to BrdU assays• Fast—results in as little as 90 minutes• Economical—more assays per kitView selection guide for all Click-iT™ EdU and Click-iT™ Plus EdU assays for flow c...
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时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
型号:
时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
型号:
时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
型号:
时间: 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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