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1
2019 - 12 - 25
前瞻记忆是指个体记住未来要完成任务的能力。儿童进入学校后,前瞻记忆任务逐渐增多,对前瞻记忆能力的要求也逐渐增高。前瞻记忆任务成功的关键在于当个体看到线索时能主动提取并执行意图。前瞻记忆线索分为三种,时间线索(如周六晚上7点记得参加朋友的生日聚会)、事件线索(如路过超市记得买水果)和活动结束线索(如写完作业记得找家长签字)。三种线索的提取难度存在差异,这可能与其对注意资源的需求不同有关。较之正常发育的儿童,多动症儿童在日常活动中常有注意力不集中和健忘的表现,提示其前瞻记忆能力可能存在缺损。然而,对多动症儿童前瞻记忆功能的研究较少,更缺乏研究直接考察多动症儿童在三种线索条件下的前瞻记忆表现及其认知加工特点。因此,中国科学院心理研究所心理健康重点实验室神经心理和应用认知神经科学(NACN)实验室陈楚侨研究组与北医六院医生钱英、潍坊医学院教授王艳郁合作考察了多动症儿童在时间、事件和活动结束线索条件下的前瞻记忆表现。该研究招募了28名临床诊断的多动症儿童和28名年龄和性别匹配的正常发育儿童,采用钓鱼游戏任务(Yang, Chan, Shum, 2011)测查儿童在三种线索条件下的前瞻记忆功能。该任务采取经典的双任务范式,主任务要求儿童钓鱼,并同时关注前瞻记忆线索,在线索出现时儿童需要停止钓鱼并执行前瞻记忆任务。在时间线索条件下,儿童要记得每到整分钟就喂猫吃鱼;在事件线索条件下,儿童看到特殊条...
2
2019 - 07 - 12
大脑每天接收的来自客观世界的感觉信息纷繁复杂,大脑对这些刺激进行分类后,人们才有感知判断。那么大脑是如何开展这项工作的呢?中科院脑科学与智能技术卓越创新中心(中科院神经科学研究所)研究员徐宁龙团队揭示了其中的奥秘,解析了大脑对感觉信息进行范畴化的皮层神经元群体运算机制。相关成果日前在线发表于《神经元》。大脑每天接收海量的来自客观世界的感觉信息,能够形成的概念和采取的行动却数目有限,为形成有意义的认知来指导行为,大脑需要对这些信息进行高效的组织管理,其中最基本的过程就是范畴化——简言之,就是分类。神经科学家本世纪初开启了信息分类和感知觉范畴化神经机制研究的新领域,但以往研究侧重神经运算的结果,对于感觉信息怎样被转化为离散的类别信息这一神经运算过程,并没有明确答案。本研究中,研究人员在小鼠中建立了一个基于听觉的分类抉择行为范式,结合活体双光子成像技术,解析了对感觉信息进行范畴化的皮层神经元群体运算机制。徐宁龙介绍,听到声音,经过训练的小鼠大脑中的一类神经元表现出对声音类别的特异性反应,将不同频率的纯音归类到 “高音” 或“低音”范畴。在高低音临界点的分类中,小鼠会“纠结”。这时大脑中的另一类神经元,表现出对类别边界频率声音的“选择性反应”,协助小鼠进行判断和分类。如果小鼠没有被要求完成分类任务,这类神经元选择性反应则“难觅踪迹”。研究表明,在听觉皮层中存在范畴抉择相关的单细胞反应,听觉...
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2019 - 06 - 24
2019年6月24日讯 /生物谷BIOON /——普林斯顿大学的Bonnie Bassler及其同事于近日在《PLOS Pathogens》上发表的一项研究表明,他们已经开发出一种新的突变型受体,这种受体被一种细菌病原体用来进行一种称为群体感应的化学交流过程。正如作者所指出的,突变受体可作为识别抑制群体感应的治疗化合物,以满足迫切的医疗需求。图片来源:McCready AR, et al. (2019)人类病原体绿脓杆菌利用群体感应来协调群体行为,包括生物膜的形成和促感染分子的产生。群体感应是绿脓杆菌成为病原体的关键,它依赖于细胞外信号分子的产生、释放和检测。自诱导因子与受体蛋白结合,共同激活群体感应基因的转录。在这项新研究中,Bassler和他的同事发现、纯化并鉴定了绿脓杆菌RhlR群体感应受体的突变版本,他们称之为RhlR*。值得注意的是,RhlR*不需要它的合作自动诱导器来工作。携带RhlR*的绿脓杆菌能正确形成生物膜,产生毒力因子,感染蛔虫。由于RhlR*不依赖于一种自动诱导剂来发挥作用,以前无法用RhlR进行的生化和遗传分析可以用RhlR*进行。这一发现为绿脓杆菌群体感应元件的工作机制提供了新的见解,其中最引人注目的是PqsE酶,它与RhlR一起控制毒力因子的产生。作者认为,RhlR*是了解绿脓杆菌细胞间通讯和毒性的一个特别有价值的工具,而绿脓杆菌是一种具有高度临床相关性...
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时间: 2019 - 04 - 15
描述This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.Additional characteristics of this EVOS® objective:• Magnification: 50X• Numerical Aperture: 0.95• Working Distance:...
型号:
时间: 2019 - 04 - 15
描述The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-sta...
型号:
时间: 2019 - 04 - 15
描述The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.The EVOS® FL Imaging System offers you these important ad...
型号:
时间: 2019 - 04 - 15
描述The EVOS® Onstage Master Plate is part of the EVOS® Onstage Incubator and holds the EVOS® Onstage Vessel Holder. The EVOS® Onstage Incubator is an environmental chamber designed specifically for use with the EVOS® FL Auto Imaging System. This master plate plus vessel holder design, with vessel holders available that accommodate various types of cell culture vessels, provides flexibility in your approach to extended time-lapse imaging experiments under precisely co...
型号:
时间: 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates two 25-mL T-flasks. With ...
型号:
时间: 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates multi-well plates (dimensi...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder securely holds two 25 x 75 mm standard or chamber microscope slides and is specific for the automated stage of the EVOS® FL Auto Imaging System. It is just one of many easy-to-change vessel holders and stage plates available for this instrument plat...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner/BD T-25 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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