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2019 - 02 - 01
复旦大学类脑智能科学与技术研究院冯建峰团队对来自英美等 6 个国家、20 余所研究机构超过 1 万例影像遗传学数据进行计算分析,通过全脑全基因组范围的 “广泛搜索”,发现与青春期大脑壳核体积相关的基因位点同时也是精神分裂症的风险位点。该成果近日发表于《美国医学会杂志—精神病学卷》。“这项研究证明青春期大脑壳核体积异常和精神分裂症致病风险高度相关。” 冯建峰表示,该发现有望帮助科学家揭示精神分裂症发病机制,为临床症状出现之前的超前干预研究提供新思路。精神疾病防治是当今世界各国面临的共同难题。据报道,在中国,精神疾病已超过心脑血管疾病和恶性肿瘤,成为医疗体系的最大负担。“大脑在不同年龄受不同遗传信息影响,此前的研究未严格控制这一混杂因素,导致重要的遗传信号被‘淹没’。” 论文第一作者、复旦大学类脑智能科学与技术研究院副研究员罗强告诉《中国科学报》,研究团队选取了 14 岁健康青少年脑结构影像数据,同时突破了传统的解剖学脑区划分限制,在全脑全基因组范围内开展无偏的探索性研究,首次找到了青少年大脑结构与基因位点之间最为显著的关联关系。同时针对该结果,研究人员进一步开展了孟德尔随机化分析,发现了一条基因—大脑—精神分裂症的新通路。“这项研究的突破主要基于对来自全球范围的多中心影像遗传学数据进行计算分析,这些全维度标准化大数据的获取,得益于多年来我们在全世界范围内深入开展的国际合作研究。” 冯...
2
2019 - 06 - 18
和50年前相比,现在人们日常卡路里摄入更多,平均每天高出650大卡,相当于每天多吃了一顿有汉堡、薯条和可乐的套餐,约占男性和女性每日所需食物能量的1/4和1/3。这些多余的卡路里不仅体现在越来越多人圆滚的腰围上,根据澳大利亚国立大学(Australian National University,ANU)的专家提醒,更会对我们的大脑带来“毁灭性”的影响。ANU团队的最新研究显示,由于不健康生活方式,大脑功能衰退可能比我们想象得更早。研究结果近日发表在Frontiers in Neuroendocrinology。根据世界卫生组织的数据,全球约有39%的成人超重,13%的成人肥胖。作为超重和肥胖的常见健康后果之一,2型糖尿病在2030年将影响约10%的成人。众所周知,2型糖尿病与大脑健康受损、认知功能退化有关,神经损伤也是糖尿病的并发症之一。那么,在还没有出现高血糖等符合糖尿病诊断的症状时,神经退行性病变和认知障碍是否也已经处于病理过程中了?又与哪些导致血糖变化的因素有关?研究团队回顾了近200项相关的国际研究,结果表明,即便是非糖尿病人群,由于血糖偏高和肥胖而导致的神经病变也在非常早期就开始了,并且从那时起就开始影响大脑健康和认知功能。比如,一项涉及澳大利亚超过7000人的PATH研究显示,哪怕血糖值尚且在正常范围内,但血糖偏高的人群,大脑中海马和杏仁核普遍萎缩更多,4年内体积约缩小...
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2019 - 02 - 22
据新华社电 美国航天局一项双胞胎对比研究显示,长期太空生活有可能会让宇航员的免疫系统处于高度警戒状态,并改变他们一些基因的活跃程度。2015 年至 2016 年,美国宇航员斯科特 · 凯利在国际空间站上连续生活 340 天,而他的双胞胎兄弟马克 · 凯利在地面生活。美国航天局利用兄弟俩开展了独特的对比研究,希望进一步了解长期太空生活对人体健康的影响。在近日召开的美国科学促进会年会上,研究人员公布了一项初步发现:接近一年的太空生活让斯科特的免疫系统变得超级活跃。免疫系统是人体防卫病原体入侵的重要防线。参与研究的美国韦尔 · 康奈尔医学院遗传学者克里斯托弗 · 梅森说,斯科特身体对太空环境的反应,就好像他体内多了一个陌生器官一般。梅森表示,斯科特体内一些与免疫系统有关的基因变得超级活跃。虽然基因本身没有改变,但其表达却有所不同,即基因的开与关、产生蛋白质的多少发生了变化。他还发现,斯科特血液中一种显示免疫系统增强的标志物增多,而一种与早期病毒防御相关的细胞类型却有所减少。研究人员表示,目前尚无法确定这些变化会对人体造成什么影响。但基因活动在太空中发生变化并不奇怪,因为人体会对环境的改变作出反应。斯科特回到地球后不久,身体各项指标就大体恢复正常。研究人员认为,双胞胎对比研究尚未发现新的重要警示信息,这对长期太空飞行来说总体上是一个令人鼓舞的消息。此...
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型号:
时间: 2019 - 04 - 15
描述This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.Additional characteristics of this EVOS® objective:• Magnification: 50X• Numerical Aperture: 0.95• Working Distance:...
型号:
时间: 2019 - 04 - 15
描述The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-sta...
型号:
时间: 2019 - 04 - 15
描述The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.The EVOS® FL Imaging System offers you these important ad...
型号:
时间: 2019 - 04 - 15
描述The EVOS® Onstage Master Plate is part of the EVOS® Onstage Incubator and holds the EVOS® Onstage Vessel Holder. The EVOS® Onstage Incubator is an environmental chamber designed specifically for use with the EVOS® FL Auto Imaging System. This master plate plus vessel holder design, with vessel holders available that accommodate various types of cell culture vessels, provides flexibility in your approach to extended time-lapse imaging experiments under precisely co...
型号:
时间: 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates two 25-mL T-flasks. With ...
型号:
时间: 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates multi-well plates (dimensi...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder securely holds two 25 x 75 mm standard or chamber microscope slides and is specific for the automated stage of the EVOS® FL Auto Imaging System. It is just one of many easy-to-change vessel holders and stage plates available for this instrument plat...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner/BD T-25 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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