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1
2020 - 05 - 08
最近,《自然—通讯》刊发了一篇针对类风湿关节炎(RA)致病和标志分子的研究。该文章来自北京大学人民医院风湿免疫研究所栗占国课题组,作者发现,RA患者的sSR-A水平显着升高,与该疾病的临床症状和免疫状况指标直接相关。结果表明sSR-A是RA诊断的新型生物标志物,尤其可用于血清阴性及早期RA的诊断,而靶向sSR-A可能是一种新的治疗策略。《中国科学报》了解到,RA是一种常见的自身免疫病,具有高致残性。全球有3000多万患者,该病以破坏性关节炎及自身免疫异常为主要特征。目前,RA的血清诊断主要依据类风湿因子和抗CCP的检测。但是,仍有大量患者在发病初期,甚至患病多年而缺乏生物标志物,给临床诊断和治疗带来困难,导致延误治疗而出现残疾。早期诊断对于改善RA的结局至关重要。但是,目前的诊断工具对早期患者敏感性有限,致使大量的患者因延误诊断,不能得以正确治疗,出现残疾。鉴于此,该研究团队联合浙江大学、南方医科大学和包头医学院的研究者展开了一项大规模的多中心研究,涉及3262名参与者的训练队列和验证队列,最终发现sSR-A是RA的致病分子,可促进炎性T细胞和致炎因子产生。并且,该课题组利用基因敲除的sSR-A-/-模型研究证明,sSR-A可以促进关节炎的发病以及病情的加重,靶向抑制sSR-A可以缓解关节炎的症状。研究者进一步证实,sSR-A蛋白可以促进胶原诱导性关节炎发病,加速病情进展,加重疾病...
2
2019 - 08 - 01
第二看台老年性黄斑变性(AMD)、视网膜色素变性(RP)等视网膜变性疾病是目前尚无有效治疗手段的凶险致盲性眼病,也是公认的 “视力杀手”。由中南大学爱尔眼科学院院长唐仕波教授、爱尔眼科研究所副所长陈建苏教授带领团队,利用诱导多能干细胞(iPS)条件培养基和飞秒角膜透镜,联合构建高活性视网膜色素上皮细胞(RPE)的研究,不但有利于对视网膜色素上皮细胞生理特性、药物筛选等研究,还有利于构建组织工程视网膜层及其移植。这将帮助科学家开发出应用组织工程 RPE 细胞片治疗视网膜变性疾病和光感受器病变的新方法。培养高活性的视网膜细胞与年龄相关的老年性黄斑变性是发达国家 50 岁以上人群视力损害和致盲的首要病因,多达 90% 的病人无法治愈。数据显示,发达国家年龄 50 岁以上黄斑变性的发病率达 11%,目前我国的发病率接近发达国家,患病人数超过 3000 万人,并以每年 30 万人次的速度增加,成为我国现阶段 50 岁以上年龄群体发病率最高的三大眼科疾病之一,而且女性呈现出比男性更高的危险性。研究发现,未来最有希望治疗老年性黄斑变性的方式是视网膜色素上皮细胞疗法、视网膜黄斑部分的移植。那么,要采用 RPE 疗法,就需要先培养健康的视网膜细胞。陈建苏告诉科技日报记者,取出死亡时间在 3 小时内捐献者的带有部分脉络膜的视网膜组织,在解剖显微镜下可将带有部分脉络膜的 RPE 层从捐赠组织中分离出来,...
3
2019 - 07 - 26
科技日报北京 7 月 30 日电 (记者付丽丽)“建立严格的法律责任制度,对违反《疫苗管理法》规定构成犯罪的,依法从重追究刑事责任,货款不足 50 万元的按 50 万元计算。”30 日,在国家药监局主办的 “《疫苗管理法》颁布法规解读宣贯研讨会上”,该局政策法规司副司长吴丽雅说。《疫苗管理法》是全球首部综合性疫苗管理法律。具体来讲,吴丽雅介绍,生产、销售的疫苗属于假药的,没收违法所得和违法生产、销售的疫苗以及专门用于违法生产疫苗的原料、辅料、包装材料、设备等物品,责令停产停业整顿,吊销药品注册证书,直至吊销药品生产许可证等,并处违法生产、销售疫苗货值金额 15 倍以上 50 倍以下的罚款。生产、销售的疫苗属于劣药的,处违法生产、销售疫苗货款金额 10 倍以上 30 倍以下罚款。吴丽雅为读者算了一笔账。生产、销售的疫苗属于假药的,最低罚款:50 万元 ×(15 倍至 50 倍)=750 万元至 2500 万元;生产、销售的疫苗属于劣药的,最低罚款: 50 万元 ×(10 倍至 30 倍)=500 万元至 1500 万元。疫苗是特殊的药品,事关公共安全。吴丽雅表示,长春长生问题疫苗事件暴露出我国在疫苗监管方面存在主体责任不落实、质量安全管理不到位、职业化专业化监管力量薄弱等问题。鉴于此,《疫苗管理法》明确提出国家对疫苗实行最严格的管理制度,对疫苗的研制、生产、流通、...
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型号:
时间: 2019 - 04 - 15
描述This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.Additional characteristics of this EVOS® objective:• Magnification: 50X• Numerical Aperture: 0.95• Working Distance:...
型号:
时间: 2019 - 04 - 15
描述The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-sta...
型号:
时间: 2019 - 04 - 15
描述The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.The EVOS® FL Imaging System offers you these important ad...
型号:
时间: 2019 - 04 - 15
描述The EVOS® Onstage Master Plate is part of the EVOS® Onstage Incubator and holds the EVOS® Onstage Vessel Holder. The EVOS® Onstage Incubator is an environmental chamber designed specifically for use with the EVOS® FL Auto Imaging System. This master plate plus vessel holder design, with vessel holders available that accommodate various types of cell culture vessels, provides flexibility in your approach to extended time-lapse imaging experiments under precisely co...
型号:
时间: 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates two 25-mL T-flasks. With ...
型号:
时间: 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates multi-well plates (dimensi...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder securely holds two 25 x 75 mm standard or chamber microscope slides and is specific for the automated stage of the EVOS® FL Auto Imaging System. It is just one of many easy-to-change vessel holders and stage plates available for this instrument plat...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner/BD T-25 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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