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7
2019 - 07 - 05
据新华社电 美国疾病控制和预防中心研究团队发现,正在刚果(金)使用的两种试验性疗法对抗击当前的埃博拉疫情有效。7 月 9 日发表在英国《柳叶刀—传染病》杂志上的研究显示,在实验室中,抗病毒药物 Remdesivir,以及由三种抗体组成的抗埃博拉药物 ZMapp 可阻断新一轮埃博拉疫情的致病毒株在人类细胞中增长。确认抗病毒药物有效的关键之一在于找到此次疫情的致病毒株。论文第一作者、美疾控中心微生物学家劳拉 · 麦克马伦说,目前在刚果(金)试用的疗法均针对以前疫情中获取的埃博拉毒株,而埃博拉是一种核糖核酸(RNA)病毒,会不断变异,因此确定现有疗法是否对新毒株奏效至关重要。美疾控中心研究人员没有当前在刚果(金)传播的 “伊图里” 毒株样本,但他们从开源基因库中获得病毒序列数据,使用 “反向遗传学” 技术重组了毒株。这项技术有助于研究人员更多了解新毒株在埃博拉家族树中的位置,从而寻找更多潜在疗法,并测试各类新疗法的有效性,还可与未来的新毒株进行比对。研究中还发现,2014 年到 2016 年西非多国爆发埃博拉疫情期间开发的一种实验室病毒诊断方法可用于诊断 “伊图里” 毒株。(周舟)文章摘自:生物360
8
2019 - 07 - 12
大脑每天接收的来自客观世界的感觉信息纷繁复杂,大脑对这些刺激进行分类后,人们才有感知判断。那么大脑是如何开展这项工作的呢?中科院脑科学与智能技术卓越创新中心(中科院神经科学研究所)研究员徐宁龙团队揭示了其中的奥秘,解析了大脑对感觉信息进行范畴化的皮层神经元群体运算机制。相关成果日前在线发表于《神经元》。大脑每天接收海量的来自客观世界的感觉信息,能够形成的概念和采取的行动却数目有限,为形成有意义的认知来指导行为,大脑需要对这些信息进行高效的组织管理,其中最基本的过程就是范畴化——简言之,就是分类。神经科学家本世纪初开启了信息分类和感知觉范畴化神经机制研究的新领域,但以往研究侧重神经运算的结果,对于感觉信息怎样被转化为离散的类别信息这一神经运算过程,并没有明确答案。本研究中,研究人员在小鼠中建立了一个基于听觉的分类抉择行为范式,结合活体双光子成像技术,解析了对感觉信息进行范畴化的皮层神经元群体运算机制。徐宁龙介绍,听到声音,经过训练的小鼠大脑中的一类神经元表现出对声音类别的特异性反应,将不同频率的纯音归类到 “高音” 或“低音”范畴。在高低音临界点的分类中,小鼠会“纠结”。这时大脑中的另一类神经元,表现出对类别边界频率声音的“选择性反应”,协助小鼠进行判断和分类。如果小鼠没有被要求完成分类任务,这类神经元选择性反应则“难觅踪迹”。研究表明,在听觉皮层中存在范畴抉择相关的单细胞反应,听觉...
9
2019 - 06 - 24
2019年6月24日讯 /生物谷BIOON /——普林斯顿大学的Bonnie Bassler及其同事于近日在《PLOS Pathogens》上发表的一项研究表明,他们已经开发出一种新的突变型受体,这种受体被一种细菌病原体用来进行一种称为群体感应的化学交流过程。正如作者所指出的,突变受体可作为识别抑制群体感应的治疗化合物,以满足迫切的医疗需求。图片来源:McCready AR, et al. (2019)人类病原体绿脓杆菌利用群体感应来协调群体行为,包括生物膜的形成和促感染分子的产生。群体感应是绿脓杆菌成为病原体的关键,它依赖于细胞外信号分子的产生、释放和检测。自诱导因子与受体蛋白结合,共同激活群体感应基因的转录。在这项新研究中,Bassler和他的同事发现、纯化并鉴定了绿脓杆菌RhlR群体感应受体的突变版本,他们称之为RhlR*。值得注意的是,RhlR*不需要它的合作自动诱导器来工作。携带RhlR*的绿脓杆菌能正确形成生物膜,产生毒力因子,感染蛔虫。由于RhlR*不依赖于一种自动诱导剂来发挥作用,以前无法用RhlR进行的生化和遗传分析可以用RhlR*进行。这一发现为绿脓杆菌群体感应元件的工作机制提供了新的见解,其中最引人注目的是PqsE酶,它与RhlR一起控制毒力因子的产生。作者认为,RhlR*是了解绿脓杆菌细胞间通讯和毒性的一个特别有价值的工具,而绿脓杆菌是一种具有高度临床相关性...
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型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型号:
时间: 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...
型号:
时间: 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
型号:
时间: 2019 - 04 - 12
描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...
型号:
时间: 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...
型号:
时间: 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...
型号:
时间: 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The GFP light cube is ideal for use with Alexa Fluor® ...
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