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PLoS Pathog：突变的细菌受体可能为对抗机会性病原体提供新的疗法
PLoS Pathog：突变的细菌受体可能为对抗机会性病原体提供新的疗法
2019 - 06 - 24
2019年6月24日讯 /生物谷BIOON /——普林斯顿大学的Bonnie Bassler及其同事于近日在《PLOS Pathogens》上发表的一项研究表明，他们已经开发出一种新的突变型受体，这种受体被一种细菌病原体用来进行一种称为群体感应的化学交流过程。正如作者所指出的，突变受体可作为识别抑制群体感应的治疗化合物，以满足迫切的医疗需求。图片来源：McCready AR, et al. (2019)人类病原体绿脓杆菌利用群体感应来协调群体行为，包括生物膜的形成和促感染分子的产生。群体感应是绿脓杆菌成为病原体的关键，它依赖于细胞外信号分子的产生、释放和检测。自诱导因子与受体蛋白结合，共同激活群体感应基因的转录。在这项新研究中，Bassler和他的同事发现、纯化并鉴定了绿脓杆菌RhlR群体感应受体的突变版本，他们称之为RhlR*。值得注意的是，RhlR*不需要它的合作自动诱导器来工作。携带RhlR*的绿脓杆菌能正确形成生物膜，产生毒力因子，感染蛔虫。由于RhlR*不依赖于一种自动诱导剂来发挥作用，以前无法用RhlR进行的生化和遗传分析可以用RhlR*进行。这一发现为绿脓杆菌群体感应元件的工作机制提供了新的见解，其中最引人注目的是PqsE酶，它与RhlR一起控制毒力因子的产生。作者认为，RhlR*是了解绿脓杆菌细胞间通讯和毒性的一个特别有价值的工具，而绿脓杆菌是一种具有高度临床相关性...
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预防痴呆从中年做起
预防痴呆从中年做起
2019 - 02 - 28
据新华社电 瑞典哥德堡大学一项新研究表明，中年时期积极进行体力和脑力活动，有助降低罹患老年痴呆症的风险。哥德堡大学研究人员近日发表在美国《神经学》杂志上的一篇论文说，他们对 800 名瑞典女性进行了长达 44 年的跟踪调查，这些女性刚参与研究时平均年龄为 47 岁，并被按照参与脑力和体力活动的情况打分及分组。该研究中，脑力活动包括阅读和写作等智力活动、听音乐会和参加合唱团等艺术活动以及做针线活等手工活动。44% 的参与者被划分到脑力活动水平较低的低分组；56% 的人被划分到高分组。对体力活动，则分为活跃组和不活跃组。每周进行 4 小时以上步行、骑单车等低强度运动，或每周有规律地进行高强度运动如跑步、游泳等，或参与竞技运动，被划分到活跃组。按此标准，17% 的参与者被视为不活跃；82% 的人被视为活跃。研究发现，在排除了高血压、抽烟和糖尿病等风险因素后，脑力活动高分组女性比低分组女性罹患阿尔茨海默病的风险低 46%，罹患老年痴呆症的总体风险低 34%；而体力活动活跃组的女性比不活跃组女性罹患血管性痴呆症的风险低 52%，罹患混合型痴呆症的风险低 56%。摘自：生物360来源：中国科学报
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听觉皮层编码听觉认知新机制获揭示
听觉皮层编码听觉认知新机制获揭示
2019 - 07 - 12
大脑每天接收的来自客观世界的感觉信息纷繁复杂，大脑对这些刺激进行分类后，人们才有感知判断。那么大脑是如何开展这项工作的呢？中科院脑科学与智能技术卓越创新中心（中科院神经科学研究所）研究员徐宁龙团队揭示了其中的奥秘，解析了大脑对感觉信息进行范畴化的皮层神经元群体运算机制。相关成果日前在线发表于《神经元》。大脑每天接收海量的来自客观世界的感觉信息，能够形成的概念和采取的行动却数目有限，为形成有意义的认知来指导行为，大脑需要对这些信息进行高效的组织管理，其中最基本的过程就是范畴化——简言之，就是分类。神经科学家本世纪初开启了信息分类和感知觉范畴化神经机制研究的新领域，但以往研究侧重神经运算的结果，对于感觉信息怎样被转化为离散的类别信息这一神经运算过程，并没有明确答案。本研究中，研究人员在小鼠中建立了一个基于听觉的分类抉择行为范式，结合活体双光子成像技术，解析了对感觉信息进行范畴化的皮层神经元群体运算机制。徐宁龙介绍，听到声音，经过训练的小鼠大脑中的一类神经元表现出对声音类别的特异性反应，将不同频率的纯音归类到 “高音” 或“低音”范畴。在高低音临界点的分类中，小鼠会“纠结”。这时大脑中的另一类神经元，表现出对类别边界频率声音的“选择性反应”，协助小鼠进行判断和分类。如果小鼠没有被要求完成分类任务，这类神经元选择性反应则“难觅踪迹”。研究表明，在听觉皮层中存在范畴抉择相关的单细胞反应，听觉...
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EVOS™ Vessel Holder, universal
产品名称： EVOS™ Vessel Holder, universal
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...
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EVOS™ Vessel Holder, Greiner T-75 flask
产品名称： EVOS™ Vessel Holder, Greiner T-75 flask
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
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EVOS™ Vessel Holder, Hemocytometer
产品名称： EVOS™ Vessel Holder, Hemocytometer
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...
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EVOS™ Vessel Holder, Nunc™ T-75 flask
产品名称： EVOS™ Vessel Holder, Nunc™ T-75 flask
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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EVOS™ Vessel Holder, two 25-cm T-flasks
产品名称： EVOS™ Vessel Holder, two 25-cm T-flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...
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EVOS™ Vessel Holder, one 100-mm Petri dish
产品名称： EVOS™ Vessel Holder, one 100-mm Petri dish
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ Vessel Holder, two 60-mm Petri dishes
产品名称： EVOS™ Vessel Holder, two 60-mm Petri dishes
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
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EVOS™ Vessel Holder, four 35-mm Petri dishes
产品名称： EVOS™ Vessel Holder, four 35-mm Petri dishes
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...
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EVOS™ Vessel Holder, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ 4X Objective, fluorite, LWD, phase-contrast
产品名称： EVOS™ 4X Objective, fluorite, LWD, phase-contrast
型号：
时间： 2019 - 04 - 12
描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...
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EVOS™ Light Cube, Cy™5
产品名称： EVOS™ Light Cube, Cy™5
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...
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EVOS™ Light Cube, RFP
产品名称： EVOS™ Light Cube, RFP
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...
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