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7
2019 - 08 - 01
第二看台老年性黄斑变性(AMD)、视网膜色素变性(RP)等视网膜变性疾病是目前尚无有效治疗手段的凶险致盲性眼病,也是公认的 “视力杀手”。由中南大学爱尔眼科学院院长唐仕波教授、爱尔眼科研究所副所长陈建苏教授带领团队,利用诱导多能干细胞(iPS)条件培养基和飞秒角膜透镜,联合构建高活性视网膜色素上皮细胞(RPE)的研究,不但有利于对视网膜色素上皮细胞生理特性、药物筛选等研究,还有利于构建组织工程视网膜层及其移植。这将帮助科学家开发出应用组织工程 RPE 细胞片治疗视网膜变性疾病和光感受器病变的新方法。培养高活性的视网膜细胞与年龄相关的老年性黄斑变性是发达国家 50 岁以上人群视力损害和致盲的首要病因,多达 90% 的病人无法治愈。数据显示,发达国家年龄 50 岁以上黄斑变性的发病率达 11%,目前我国的发病率接近发达国家,患病人数超过 3000 万人,并以每年 30 万人次的速度增加,成为我国现阶段 50 岁以上年龄群体发病率最高的三大眼科疾病之一,而且女性呈现出比男性更高的危险性。研究发现,未来最有希望治疗老年性黄斑变性的方式是视网膜色素上皮细胞疗法、视网膜黄斑部分的移植。那么,要采用 RPE 疗法,就需要先培养健康的视网膜细胞。陈建苏告诉科技日报记者,取出死亡时间在 3 小时内捐献者的带有部分脉络膜的视网膜组织,在解剖显微镜下可将带有部分脉络膜的 RPE 层从捐赠组织中分离出来,...
8
2020 - 05 - 08
最近,《自然—通讯》刊发了一篇针对类风湿关节炎(RA)致病和标志分子的研究。该文章来自北京大学人民医院风湿免疫研究所栗占国课题组,作者发现,RA患者的sSR-A水平显着升高,与该疾病的临床症状和免疫状况指标直接相关。结果表明sSR-A是RA诊断的新型生物标志物,尤其可用于血清阴性及早期RA的诊断,而靶向sSR-A可能是一种新的治疗策略。《中国科学报》了解到,RA是一种常见的自身免疫病,具有高致残性。全球有3000多万患者,该病以破坏性关节炎及自身免疫异常为主要特征。目前,RA的血清诊断主要依据类风湿因子和抗CCP的检测。但是,仍有大量患者在发病初期,甚至患病多年而缺乏生物标志物,给临床诊断和治疗带来困难,导致延误治疗而出现残疾。早期诊断对于改善RA的结局至关重要。但是,目前的诊断工具对早期患者敏感性有限,致使大量的患者因延误诊断,不能得以正确治疗,出现残疾。鉴于此,该研究团队联合浙江大学、南方医科大学和包头医学院的研究者展开了一项大规模的多中心研究,涉及3262名参与者的训练队列和验证队列,最终发现sSR-A是RA的致病分子,可促进炎性T细胞和致炎因子产生。并且,该课题组利用基因敲除的sSR-A-/-模型研究证明,sSR-A可以促进关节炎的发病以及病情的加重,靶向抑制sSR-A可以缓解关节炎的症状。研究者进一步证实,sSR-A蛋白可以促进胶原诱导性关节炎发病,加速病情进展,加重疾病...
9
2018 - 06 - 14
2018年6月13日讯 /生物谷BIOON/ --阿尔茨海默氏症(AD)一直是新药研发的重灾区,该领域研发失败率高达99.6%。过去几年,包括礼来、阿斯利康、强生、辉瑞、罗氏在内的制药巨头投资达数十亿美元之巨的多个单抗药物均在III期临床惨遭失败,为该领域的投资前景蒙上了厚厚的阴云。之后,另一个很有前途的新药类别——BACE抑制剂,成功取代抗体药物站在了AD研发的舞台中央。然而,BACE抑制剂似乎也不大可能打破魔咒,正在追随着单抗药物的步伐。去年情人节当天,BACE抑制剂领域的领头羊——默沙东宣布终止verubecestat治疗轻至中度AD的大型III期研究EPOCH(protocol 017);今年情人节前一天,默沙东再次宣布终止verubecestat治疗前驱期AD的大型III期研究APECS(protocol 019)。这也意味着,verubecestat治疗AD的III期临床项目已完全终止。而2次公告时间均选在情人节,特别耐人寻味,默沙东似乎在述说着心中的苦楚和不舍,而这一点,一大票巨头们都深有感触:AD,AD,想说爱你,真的不易o(╥﹏╥)o!就在昨天,礼来和阿斯利康哥俩,手牵手沿着BACE国道,哭喊着朝默沙东奔去,原因竟然是——————————他们的BACE抑制剂也O-O-O-O-OVER了!!!根据公告,双方将终止lanabecestat的全球III期项目,包括lan...
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型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
型号:
时间: 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
型号:
时间: 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...
型号:
时间: 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
型号:
时间: 2019 - 04 - 12
描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...
型号:
时间: 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...
型号:
时间: 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...
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