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青蛙肺部能充当“降噪耳机”
青蛙肺部能充当“降噪耳机”
2021 - 06 - 01
为了成功交配，许多雄蛙会坐在一起，向潜在配偶发出叫声。这时，问题就出现了——每个试图在人声鼎沸的鸡尾酒会上听清别人说话的人都会遇到：一只雌蛙是如何在背景噪音（包括其他蛙类的声音）中听到并找到自己的如意郎君呢？现在，研究人员可能找到了答案。3月5日，一篇发表在Cell Press细胞出版社旗下期刊Current Biology（《当代生物学》）上的报告显示，青蛙能做到这一点要归功于它们的肺部。当肺部膨胀时，青蛙鼓膜在特定的频率范围内降低了对环境噪音的敏感性，从而更容易关注配偶的叫声。 “从本质上讲，肺消除了鼓膜对噪音的反应，特别是对一些不在调上的‘繁殖大合唱’中所遇到的噪音。”论文主要作者、明尼苏达大学圣奥拉夫学院的Norman Lee说。 研究人员解释说，青蛙肺部所做的事情被称为“声谱对比度增强”。这是因为，与相邻频率的噪声相比，它使雄性声谱的频率尤为突出。 “这类似于某些助听器和耳蜗植入物中用于增强声谱对比度的信号处理算法。”明尼苏达大学双城校区的资深作者Mark Bee说，“人类设计这种算法，用来放大或提升语音的频率，减弱或过滤语音之间的频率，或两者兼而有之。青蛙的肺部似乎会减弱雄性交配叫声之间的频率。我们认为，这种现象发生的物理机制与降噪耳机的工作原理类似。” 科学家们早就知道，声音信号是大多数青蛙繁殖的关键。事实上，青蛙拥有一种独特的...
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20年研究！Nature证实：自噬，延长寿命、改善健康的关键！
20年研究！Nature证实：自噬，延长寿命、改善健康的关键！
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究，得克萨斯大学西南医学中心（UT Southwestern）自噬研究中心的主任Beth Levine和团队已经明确：细胞自噬可以延长寿命、改善健康。他们以小鼠为模型发现，自噬水平提高的小鼠寿命更长、更健康。“具体来说，它们的寿命延长了约10%，且不太可能发生与年龄相关的自发性癌症、心脏病等疾病。”Beth Levine表示道。细胞自噬自噬是一种保护机制。当细胞内出现衰老的蛋白质、损坏的细胞器等废弃物时，自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用，从而确保细胞本身的代谢需求和某些细胞器的更新。细胞自噬过程（图片来源：华威大学）20年前，Beth Levine和同事发现了自噬生物学过程中的一个关键基因beclin 1。他们还发现，自噬对于健康而言必不可少，例如预防神经衰退性疾病、对抗癌症和感染。2003年，Beth Levine团队证实，自噬关联的基因机制对于长寿突变线虫（long-lived mutant roundworms）的寿命延长至关重要。“从那以后，关于‘自噬是延长寿命的关键机制’的观点尤为火热。” Beth Levine解释道，“随着年龄增长，细胞的自噬能力会下降，这可能会导致衰老。”自噬延长寿命然而，一个关键问题仍然没有得到解答：增强自噬水平是否有益于哺乳动物的健康？换句...
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抗高血脂药物诱导自噬为治疗 AD 带来新思路
抗高血脂药物诱导自噬为治疗 AD 带来新思路
2019 - 05 - 06
来源： 中国科学报年初，一部电视剧《都挺好》火遍全国，大结局时剧中一直让人恨得牙痒痒的 “作爹” 苏大强，因患上了阿尔茨海默氏症（AD，俗称老年痴呆症）而成功“洗白”，惹出了不少人的眼泪。阿尔茨海默氏症离我们并不遥远，由它引发的故事也是常有耳闻，大多伴随着无奈与辛酸。随着全球老龄化进程的加快，愈来愈多的阿尔茨海默氏症患者将给家属及社会带来沉重的负担。根据国际阿尔茨海默氏病协会的统计数据，2018 年全世界有 5000 万老人患有痴呆，每 3 秒钟，就有 1 位患者产生；中国是阿尔茨海默氏病的重灾区，估计有 1000 万患者。关于阿尔茨海默氏症发病机制和治疗方法的研究一直都是科研界关注的重点之一。近日，中国科学院昆明动物研究所姚永刚课题组在阿尔茨海默氏症的治疗研究上取得重要进展，该研究阐明了核受体过氧化物酶体α激动剂吉非罗齐和匹立尼酸的抗阿尔茨海默氏症分子机制。相关论文在线发表于《自噬》（Autophagy）杂志上。诱导自噬，清除 Aβ作为发生在老年前期与老年期的一种常见的神经退行性脑病，阿尔茨海默氏症是最常见的老年痴呆类型，其发病率随着年龄增长而显著增加。其临床表现为病人渐进性记忆丧失、认知能力下降并伴有焦虑等其他精神相关症状。对于阿尔茨海默氏症的发病机制，现有很多学说，其中影响最广泛的有β- 淀粉样蛋白（β-amyloid，Aβ）瀑布理论，认为 Aβ的生成与清除失衡是导致神经元变...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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7-AAD (7-Aminoactinomycin D)
产品名称： 7-AAD (7-Aminoactinomycin D)
型号：
时间： 2019 - 04 - 17
描述7-aminoactinomycin D (7-AAD) is a fluorescent intercalator that undergoes a spectral shift upon association with DNA. 7-AAD/DNA complexes can be excited by the 488 nm laser and has an emission maxima of 647 nm, making this nucleic acid stain useful for multicolor fluorescence microscopy and flow cytometry. 7-AAD appears to be generally excluded from live cells, but can be used with cells that have been fixed and permeabilized. 7-AAD has been used for cell cycle analysis by flow cytometry....
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Dynabeads™ CD45
产品名称： Dynabeads™ CD45
型号：
时间： 2019 - 04 - 17
DescriptionDynabeads® CD45 are superparamagnetic beads covalently coupled to anti-human CD45 antibody that enable isolation or depletion of CD45+ leucocytes directly from whole blood, buffy coat, or MNC suspensions. Dynabeads® CD45 can also be used to enrich epithelial tumor cells. The CD45 antigen is weakly expressed on myeloid cells. To efficiently deplete or isolate all leucocytes including myeloid cells, use Dynabeads® CD15 (Cat. No. 11137D) in combination with Dynabeads®...
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EVOS™ 50X Oil Objective, achromat, coverslip-corrected
产品名称： EVOS™ 50X Oil Objective, achromat, coverslip-corrected
型号：
时间： 2019 - 04 - 15
描述This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.Additional characteristics of this EVOS® objective:• Magnification: 50X• Numerical Aperture: 0.95• Working Distance:...
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EVOS™ M7000 Imaging System
产品名称： EVOS™ M7000 Imaging System
型号：
时间： 2019 - 04 - 15
描述The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-sta...
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EVOS™ FL Imaging System
产品名称： EVOS™ FL Imaging System
型号：
时间： 2019 - 04 - 15
描述The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.The EVOS® FL Imaging System offers you these important ad...
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EVOS™ Onstage Master Plate
产品名称： EVOS™ Onstage Master Plate
型号：
时间： 2019 - 04 - 15
描述The EVOS® Onstage Master Plate is part of the EVOS® Onstage Incubator and holds the EVOS® Onstage Vessel Holder. The EVOS® Onstage Incubator is an environmental chamber designed specifically for use with the EVOS® FL Auto Imaging System. This master plate plus vessel holder design, with vessel holders available that accommodate various types of cell culture vessels, provides flexibility in your approach to extended time-lapse imaging experiments under precisely co...
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EVOS™ Onstage Vessel Holder, two 25-mL flasks
产品名称： EVOS™ Onstage Vessel Holder, two 25-mL flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates two 25-mL T-flasks. With ...
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EVOS™ Onstage Vessel Holder, multi-well plates
产品名称： EVOS™ Onstage Vessel Holder, multi-well plates
型号：
时间： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates multi-well plates (dimensi...
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EVOS™ Vessel Holder for Automated Stage, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder for Automated Stage, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder securely holds two 25 x 75 mm standard or chamber microscope slides and is specific for the automated stage of the EVOS® FL Auto Imaging System. It is just one of many easy-to-change vessel holders and stage plates available for this instrument plat...
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