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科学家警告不应低估微生物在气候变化中的作用
科学家警告不应低估微生物在气候变化中的作用
2019 - 07 - 19
近日，来自 9 个国家的 33 名微生物学家在《自然综述：微生物学》上发文表示，应该进一步将微生物融入主流气候变化研究和气候变化框架中，以应对人为造成的气候变化问题。他们警告说，“提醒人类注意，气候变化的影响将严重依赖微生物的反应，它们对于实现一个环境可持续发展的未来至关重要”。已知人类活动及其对气候和环境的影响关系到动植物灭绝和生物多样性损失，并且危及地球上的动植物生命。微生物也会对温室气体排放产生重要影响。尽管微生物丰富多样，但它们维护生态系统健康的作用，以及如何影响气候变化或被气候变化影响，却鲜为人知。澳大利亚新南威尔士大学的 Ricardo Cavicchioli 等人认为，微生物在气候变化生物学中扮演的核心角色及其全局重要性不应被低估，他们并且呼吁研究人员、机构和政府对微生物加剧或缓解人为气候变化影响的作用进行评估。研究人员在文中探讨了气候变化对微生物作用以及全球海陆生物群落的影响。他们还指出，从农业和传染病的角度出发，需要更深入地理解气候变化对微生物的影响，比如气候变化预计将提高部分人类病原体的抗生素耐药性。相关论文信息：https://doi.org/10.1038/s41579-019-0222-5
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两种疗法可有效对抗埃博拉疫情
两种疗法可有效对抗埃博拉疫情
2019 - 07 - 05
据新华社电 美国疾病控制和预防中心研究团队发现，正在刚果（金）使用的两种试验性疗法对抗击当前的埃博拉疫情有效。7 月 9 日发表在英国《柳叶刀—传染病》杂志上的研究显示，在实验室中，抗病毒药物 Remdesivir，以及由三种抗体组成的抗埃博拉药物 ZMapp 可阻断新一轮埃博拉疫情的致病毒株在人类细胞中增长。确认抗病毒药物有效的关键之一在于找到此次疫情的致病毒株。论文第一作者、美疾控中心微生物学家劳拉 · 麦克马伦说，目前在刚果（金）试用的疗法均针对以前疫情中获取的埃博拉毒株，而埃博拉是一种核糖核酸（RNA）病毒，会不断变异，因此确定现有疗法是否对新毒株奏效至关重要。美疾控中心研究人员没有当前在刚果（金）传播的 “伊图里” 毒株样本，但他们从开源基因库中获得病毒序列数据，使用 “反向遗传学” 技术重组了毒株。这项技术有助于研究人员更多了解新毒株在埃博拉家族树中的位置，从而寻找更多潜在疗法，并测试各类新疗法的有效性，还可与未来的新毒株进行比对。研究中还发现，2014 年到 2016 年西非多国爆发埃博拉疫情期间开发的一种实验室病毒诊断方法可用于诊断 “伊图里” 毒株。（周舟）文章摘自：生物360
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听觉皮层编码听觉认知新机制获揭示
听觉皮层编码听觉认知新机制获揭示
2019 - 07 - 12
大脑每天接收的来自客观世界的感觉信息纷繁复杂，大脑对这些刺激进行分类后，人们才有感知判断。那么大脑是如何开展这项工作的呢？中科院脑科学与智能技术卓越创新中心（中科院神经科学研究所）研究员徐宁龙团队揭示了其中的奥秘，解析了大脑对感觉信息进行范畴化的皮层神经元群体运算机制。相关成果日前在线发表于《神经元》。大脑每天接收海量的来自客观世界的感觉信息，能够形成的概念和采取的行动却数目有限，为形成有意义的认知来指导行为，大脑需要对这些信息进行高效的组织管理，其中最基本的过程就是范畴化——简言之，就是分类。神经科学家本世纪初开启了信息分类和感知觉范畴化神经机制研究的新领域，但以往研究侧重神经运算的结果，对于感觉信息怎样被转化为离散的类别信息这一神经运算过程，并没有明确答案。本研究中，研究人员在小鼠中建立了一个基于听觉的分类抉择行为范式，结合活体双光子成像技术，解析了对感觉信息进行范畴化的皮层神经元群体运算机制。徐宁龙介绍，听到声音，经过训练的小鼠大脑中的一类神经元表现出对声音类别的特异性反应，将不同频率的纯音归类到 “高音” 或“低音”范畴。在高低音临界点的分类中，小鼠会“纠结”。这时大脑中的另一类神经元，表现出对类别边界频率声音的“选择性反应”，协助小鼠进行判断和分类。如果小鼠没有被要求完成分类任务，这类神经元选择性反应则“难觅踪迹”。研究表明，在听觉皮层中存在范畴抉择相关的单细胞反应，听觉...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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7-AAD (7-Aminoactinomycin D)
产品名称： 7-AAD (7-Aminoactinomycin D)
型号：
时间： 2019 - 04 - 17
描述7-aminoactinomycin D (7-AAD) is a fluorescent intercalator that undergoes a spectral shift upon association with DNA. 7-AAD/DNA complexes can be excited by the 488 nm laser and has an emission maxima of 647 nm, making this nucleic acid stain useful for multicolor fluorescence microscopy and flow cytometry. 7-AAD appears to be generally excluded from live cells, but can be used with cells that have been fixed and permeabilized. 7-AAD has been used for cell cycle analysis by flow cytometry....
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Dynabeads™ CD45
产品名称： Dynabeads™ CD45
型号：
时间： 2019 - 04 - 17
DescriptionDynabeads® CD45 are superparamagnetic beads covalently coupled to anti-human CD45 antibody that enable isolation or depletion of CD45+ leucocytes directly from whole blood, buffy coat, or MNC suspensions. Dynabeads® CD45 can also be used to enrich epithelial tumor cells. The CD45 antigen is weakly expressed on myeloid cells. To efficiently deplete or isolate all leucocytes including myeloid cells, use Dynabeads® CD15 (Cat. No. 11137D) in combination with Dynabeads®...
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EVOS™ 50X Oil Objective, achromat, coverslip-corrected
产品名称： EVOS™ 50X Oil Objective, achromat, coverslip-corrected
型号：
时间： 2019 - 04 - 15
描述This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.Additional characteristics of this EVOS® objective:• Magnification: 50X• Numerical Aperture: 0.95• Working Distance:...
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EVOS™ M7000 Imaging System
产品名称： EVOS™ M7000 Imaging System
型号：
时间： 2019 - 04 - 15
描述The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-sta...
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EVOS™ FL Imaging System
产品名称： EVOS™ FL Imaging System
型号：
时间： 2019 - 04 - 15
描述The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.The EVOS® FL Imaging System offers you these important ad...
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EVOS™ Onstage Master Plate
产品名称： EVOS™ Onstage Master Plate
型号：
时间： 2019 - 04 - 15
描述The EVOS® Onstage Master Plate is part of the EVOS® Onstage Incubator and holds the EVOS® Onstage Vessel Holder. The EVOS® Onstage Incubator is an environmental chamber designed specifically for use with the EVOS® FL Auto Imaging System. This master plate plus vessel holder design, with vessel holders available that accommodate various types of cell culture vessels, provides flexibility in your approach to extended time-lapse imaging experiments under precisely co...
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EVOS™ Onstage Vessel Holder, two 25-mL flasks
产品名称： EVOS™ Onstage Vessel Holder, two 25-mL flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates two 25-mL T-flasks. With ...
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EVOS™ Onstage Vessel Holder, multi-well plates
产品名称： EVOS™ Onstage Vessel Holder, multi-well plates
型号：
时间： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates multi-well plates (dimensi...
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EVOS™ Vessel Holder for Automated Stage, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder for Automated Stage, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder securely holds two 25 x 75 mm standard or chamber microscope slides and is specific for the automated stage of the EVOS® FL Auto Imaging System. It is just one of many easy-to-change vessel holders and stage plates available for this instrument plat...
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EVOS™Vessel Holder, Greiner/BD T-25 flask
产品名称： EVOS™Vessel Holder, Greiner/BD T-25 flask
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner/BD T-25 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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EVOS™ Vessel Holder, universal
产品名称： EVOS™ Vessel Holder, universal
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...
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