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预防痴呆从中年做起
预防痴呆从中年做起
2019 - 02 - 28
据新华社电 瑞典哥德堡大学一项新研究表明，中年时期积极进行体力和脑力活动，有助降低罹患老年痴呆症的风险。哥德堡大学研究人员近日发表在美国《神经学》杂志上的一篇论文说，他们对 800 名瑞典女性进行了长达 44 年的跟踪调查，这些女性刚参与研究时平均年龄为 47 岁，并被按照参与脑力和体力活动的情况打分及分组。该研究中，脑力活动包括阅读和写作等智力活动、听音乐会和参加合唱团等艺术活动以及做针线活等手工活动。44% 的参与者被划分到脑力活动水平较低的低分组；56% 的人被划分到高分组。对体力活动，则分为活跃组和不活跃组。每周进行 4 小时以上步行、骑单车等低强度运动，或每周有规律地进行高强度运动如跑步、游泳等，或参与竞技运动，被划分到活跃组。按此标准，17% 的参与者被视为不活跃；82% 的人被视为活跃。研究发现，在排除了高血压、抽烟和糖尿病等风险因素后，脑力活动高分组女性比低分组女性罹患阿尔茨海默病的风险低 46%，罹患老年痴呆症的总体风险低 34%；而体力活动活跃组的女性比不活跃组女性罹患血管性痴呆症的风险低 52%，罹患混合型痴呆症的风险低 56%。摘自：生物360来源：中国科学报
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听觉皮层编码听觉认知新机制获揭示
听觉皮层编码听觉认知新机制获揭示
2019 - 07 - 12
大脑每天接收的来自客观世界的感觉信息纷繁复杂，大脑对这些刺激进行分类后，人们才有感知判断。那么大脑是如何开展这项工作的呢？中科院脑科学与智能技术卓越创新中心（中科院神经科学研究所）研究员徐宁龙团队揭示了其中的奥秘，解析了大脑对感觉信息进行范畴化的皮层神经元群体运算机制。相关成果日前在线发表于《神经元》。大脑每天接收海量的来自客观世界的感觉信息，能够形成的概念和采取的行动却数目有限，为形成有意义的认知来指导行为，大脑需要对这些信息进行高效的组织管理，其中最基本的过程就是范畴化——简言之，就是分类。神经科学家本世纪初开启了信息分类和感知觉范畴化神经机制研究的新领域，但以往研究侧重神经运算的结果，对于感觉信息怎样被转化为离散的类别信息这一神经运算过程，并没有明确答案。本研究中，研究人员在小鼠中建立了一个基于听觉的分类抉择行为范式，结合活体双光子成像技术，解析了对感觉信息进行范畴化的皮层神经元群体运算机制。徐宁龙介绍，听到声音，经过训练的小鼠大脑中的一类神经元表现出对声音类别的特异性反应，将不同频率的纯音归类到 “高音” 或“低音”范畴。在高低音临界点的分类中，小鼠会“纠结”。这时大脑中的另一类神经元，表现出对类别边界频率声音的“选择性反应”，协助小鼠进行判断和分类。如果小鼠没有被要求完成分类任务，这类神经元选择性反应则“难觅踪迹”。研究表明，在听觉皮层中存在范畴抉择相关的单细胞反应，听觉...
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Nat Mater：研究揭示癌症转移的新机制
Nat Mater：研究揭示癌症转移的新机制
2020 - 02 - 14
2020年2月12日讯 /生物谷BIOON /--弗朗西斯克里克研究所(Francis Crick Institute)的研究人员发现了一种控制组织结构的关键机制，这种机制可能有助于识别使癌细胞更难扩散的药物。这项发表在《Nature Materials》上的研究解释了导致组织结构变化的机制。这些研究利用实验生物学和计算生物学，确定了细胞之间的碰撞如何帮助创建不同的组织结构。其中一些结构有助于癌症扩散，作者还发现了抑制这一过程的药物。图片来源：Nature Materials体内的所有组织都含有维持其结构的蛋白质支架。这种支架会随着人的衰老而退化，导致出现皱纹等衰老迹象。癌细胞可以破坏支架的形状，从而创造出一个组织结构，并通过各种途径从肿瘤进入周围组织。癌细胞利用这些超级高速公路沿着它们扩散到新的区域。然而，虽然我们知道这些超级高速公路与癌症的发展有关，但对于控制这些组织结构形成的机制却知之甚少。克里克肿瘤细胞生物学实验室的研究科学家Danielle Park说：'这些超级高速公路为癌细胞走出肿瘤并在组织中更广泛地扩散提供了道路，这可能会给病人带来灾难性的后果。通过更多地了解这种结构是如何形成的，我们就能找到阻止它的方法，并对癌细胞的扩散设置障碍。'通过将实验室实验的观察结果与该团队开发的新计算机模型的结果相结合，研究人员发现了组织支架的形状如何受到其与帮助构建支架...
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EVOS™ Vessel Holder, two 25-cm T-flasks
产品名称： EVOS™ Vessel Holder, two 25-cm T-flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...
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EVOS™ Vessel Holder, one 100-mm Petri dish
产品名称： EVOS™ Vessel Holder, one 100-mm Petri dish
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ Vessel Holder, two 60-mm Petri dishes
产品名称： EVOS™ Vessel Holder, two 60-mm Petri dishes
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
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EVOS™ Vessel Holder, four 35-mm Petri dishes
产品名称： EVOS™ Vessel Holder, four 35-mm Petri dishes
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...
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EVOS™ Vessel Holder, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ 4X Objective, fluorite, LWD, phase-contrast
产品名称： EVOS™ 4X Objective, fluorite, LWD, phase-contrast
型号：
时间： 2019 - 04 - 12
描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...
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EVOS™ Light Cube, Cy™5
产品名称： EVOS™ Light Cube, Cy™5
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...
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EVOS™ Light Cube, RFP
产品名称： EVOS™ Light Cube, RFP
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...
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EVOS™ Light Cube, GFP
产品名称： EVOS™ Light Cube, GFP
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The GFP light cube is ideal for use with Alexa Fluor® ...
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EVOS™ Light Cube, DAPI
产品名称： EVOS™ Light Cube, DAPI
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The DAPI light cube is ideal for use with Acridine, Alexa F...
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EVOS™ Power Cord, Type I (Australia)
产品名称： EVOS™ Power Cord, Type I (Australia)
型号：
时间： 2019 - 04 - 12
描述This power cord is for use with EVOS® XL, FL , FL Color, and FL Auto systems in countries with Type I power plugs. The Type I electrical plug is mainly used in Australia and New Zealand, but is also used in China and parts of Asia, South America, and Africa.
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EVOS™ 20X Objective, achromat, LWD, phase-contrast
产品名称： EVOS™ 20X Objective, achromat, LWD, phase-contrast
型号：
时间： 2019 - 04 - 11
描述This achromat objective is ideal for general applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnificati...
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