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1
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究,得克萨斯大学西南医学中心(UT Southwestern)自噬研究中心的主任Beth Levine和团队已经明确:细胞自噬可以延长寿命、改善健康。他们以小鼠为模型发现,自噬水平提高的小鼠寿命更长、更健康。“具体来说,它们的寿命延长了约10%,且不太可能发生与年龄相关的自发性癌症、心脏病等疾病。”Beth Levine表示道。细胞自噬自噬是一种保护机制。当细胞内出现衰老的蛋白质、损坏的细胞器等废弃物时,自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用,从而确保细胞本身的代谢需求和某些细胞器的更新。细胞自噬过程(图片来源:华威大学)20年前,Beth Levine和同事发现了自噬生物学过程中的一个关键基因beclin 1。他们还发现,自噬对于健康而言必不可少,例如预防神经衰退性疾病、对抗癌症和感染。2003年,Beth Levine团队证实,自噬关联的基因机制对于长寿突变线虫(long-lived mutant roundworms)的寿命延长至关重要。“从那以后,关于‘自噬是延长寿命的关键机制’的观点尤为火热。” Beth Levine解释道,“随着年龄增长,细胞的自噬能力会下降,这可能会导致衰老。”自噬延长寿命然而,一个关键问题仍然没有得到解答:增强自噬水平是否有益于哺乳动物的健康?换句...
2
2019 - 04 - 20
新华社武汉 4 月 19 日电(记者谭元斌)我国科研人员的一项最新研究表明,人神经前体细胞可以利用 RNA 干扰抗病毒免疫抵抗寨卡病毒感染。这一研究首次发现 RNA 干扰抗病毒免疫机制在人类神经发育过程中的关键作用,相关研究成果近期以封面文章的形式发表在国际知名期刊《细胞研究》上。在这项研究中,中国科学院武汉病毒研究所、军事科学院军事医学研究院、中国科学院动物研究所科研人员组成的联合研究团队,从寨卡病毒对人神经前体细胞独特的感染嗜性入手,首次在病毒自然感染的条件下证明了 RNA 干扰抗病毒免疫在人类细胞中的重要抗病毒作用。专家认为,人神经前体细胞中 RNA 干扰抗病毒通路的存在,为相应抗病毒药物的研发提供了新的靶标。他们发现,临床上广泛使用的 “老药” 依诺沙星能增强人神经前体细胞内 RNA 干扰的活性,在人神经前体细胞及由此分化产生的类脑器官中显示出非常高效的抗病毒作用,阻断了寨卡病毒感染所致的小头畸形表型。在同期的《细胞研究》上,刊登了世界著名病毒学家史佩勇教授对这项研究成果的评述文章。他在文章中评价这是 RNA 干扰研究的一项十分重要的进展。据中国科学院武汉病毒研究所专家介绍,RNA 干扰是生物体内普遍存在的一种古老的生物学现象,对控制生物体内基因表达起关键作用。而其作为人类中的一种重要抗病毒免疫机制,则是近年来由我国及欧美科学家的一系列研究共同发现。同时,RNA 干扰作为一...
3
2019 - 08 - 30
最近,《自然》杂志报道了不少关于癌症的研究。上周,学术经纬团队分享了一则癌症研究的重要突破——通过荧光标记,科学家们能够看清癌细胞如何“腐蚀”周边的健康细胞,发生转移。今天,我们又读到了一篇关于癌症转移的最新论文,它深刻揭示了癌症转移的复杂性,并提醒我们,在攻克癌症的道路上,我们还有很长的路要走……先来聊聊癌症。我们知道,癌症的发展就好像是一个熊孩子长大一样,会分成不同的阶段。在早期,癌细胞会疯狂生长,侵入和传播(invasion and dissemination)到组织内,在身体里形成肿瘤。到了晚期,癌细胞则会发生转移(metastasis),跑到身体的其他器官里落地生根,形成新的病灶。现在的医学知识告诉我们,一旦癌症发生了转移,患者的生命就岌岌可危。可是,癌细胞在一个地方长得好好的,它为啥会发生转移呢?过去的很多科学家相信,这与一种叫做E-cadherin(E-钙粘蛋白)的蛋白质有关。从功能上看,它负责把不同的细胞“粘”在一起。如果癌细胞能够减少这种钙粘蛋白的表达,就会变得更有“活动性”,也更容易发生转移。不过,科学家们也观察到了一些例外——在一种叫做“乳腺导管癌”的癌症中,发生转移的癌细胞,里头的E-钙粘蛋白含量可不少。这是为啥呢?有科学家解释说,这是因为癌细胞慢慢地又把自己“粘”回到了一起。这听起来是个合理的解释,但没有让所有人感到信服。为了寻找其他原因,来自美国知名的约...
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产品名称:

EVOS™ FL Imaging System

上市日期: 2019-04-15
产品类别: EVOS

规格

Color:Transmitted Light
Data Output:BMP Files, JPG Files, PNG Files, TIFF Files
Detection Method:Fluorescent
Dimensions:36 cm (14 in) (W) x 58 cm (23 in) (H) x 47 cm (19 in) (D)
Display Interface:15-inch color monitor, Adjustable tilt
For Use With (Equipment):Fluorescence Microscope
Format:Specific Holder Attachments
Frequency:50⁄60 Hz
Input Voltage:100-240 VAC
Objectives:5 Objective Turret
Product Line:EVOS®
Product Size:1 each
Stage:Mechanical stage with X-Y axis fine-positioning controls
Weight:15.3 kg (33.7 lbs)


  • 产品描述
  • 产品功能
  • 产品参数

描述

The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.

The EVOS® FL Imaging System offers you these important advantages:

• Easy installation; no maintenance, assembly, alignment, or calibration
• For four-color fluorescence and transmitted light applications
• Five-position objective turret with front controls
• On-board software
• All-in-one design: digital camera, precision optics, LCD display, and USB storage

Fully Integrated Imaging System
The EVOS® FL system represents a new concept in transmitted light inverted microscopy. It is a fully integrated imaging system that combines precision optics, a 15' high-resolution LCD display, and a highly sensitive Sony ICX445 monochrome CCD camera (1280 x 960 pixel resolution, 1.3 Megapixels). Images are seamlessly acquired through the intuitive user interface using a mouse for easy control. Monochrome cameras are commonly used for high-performance fluorescence applications and provide the best sensitivity for detection of faint fluorescence signals. Color cameras, as on the EVOS® FL Color System, have lower fluorescence sensitivity but have the advantage of being able to differentiate structures by color in transmitted light (e.g., imaging stained tissue samples).

Compare cell imaging systems >

Versatile and Highly Configurable
The EVOS® FL system features an easily accessible 5-position objective turret and a 3-position condenser turret. The 4 fluorescence light cubes are lever-actioned for rapid and easy selection. The optical system can be configured to best meet your needs using our full range of high-quality objectives from 2x to 100x magnification. Lighting settings are automatically adjusted to match the objective magnification. The EVOS® FL system features a mechanical stage with X/Y-axis fine-positioning using control knobs conveniently located on the left side and the front of the stage. The stage accommodates EVOS® vessel holders that provide a perfect fit for most vessel types and sizes. Interchangeable stage plates accommodate most vessel types and sizes, including flasks, Petri dishes, multi-well plates, and slides.

Smart LED Illumination Technology
All EVOS® fluorescence imaging systems utilize our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light-path that delivers superior fluorophore excitation. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels, dramatically improving control over photobleaching. Hard-coated filters give sharper edges and significantly higher transmission efficiencies than traditional soft-coated filters.

Integrated Software
The on-board computer makes the EVOS® FL system easy to run and use, and the intuitive, comprehensive software facilitates both image acquisition and analysis. Modules include time-lapse acquisition, manual-assist cell counting, and image review. Saved user settings work in conjunction with 'smart' controls to help increase efficiency and ease of use. Image data are saved to a USB flash drive for easy, portable data transfer or to a Windows-networked local server. Images can be saved in PNG, JPEG, BMP, and TIFF formats with a maximum captured image resolution of 1280 x 960 pixels.

These features make the EVOS® FL system ideal for both routine and demanding fluorescence imaging applications such as GFP-vector transfection efficiency analysis, routine cell and tissue culture, cell confluence determination, stem cell growth and differentiation, and developmental biology and tissue slice analyses. And the compact footprint makes it as easy to use the EVOS® FL system in a cell culture hood as on the bench.

Easy to Use and Reliable
The EVOS® FL Imaging System is plug-and-play. In addition to an exceptionally easy set-up and installation, it requires no warm-up or cool-down periods. The LED light source offers exceptional stability and durability—so you can turn the unit on and off whenever you need to image a sample. The environmentally safe mercury-free LED bulbs are rated for >50,000 hours (~17 years) of life, compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. The long life and low energy consumption translate into significantly lower operating costs compared to instruments with conventional light sources. Finally, the advanced ergonomic design of the EVOS® systems removes the strain associated with conventional microscopes, enables shared viewing, and makes moving the units easy. For extended or precision use, the EVOS® arm rest provides comfortable support.

The EVOS® imaging systems are built from the ground up to maximize performance and optimize workflow. You will be astonished at how easy it is to operate and amazed at how extraordinary your images look on-screen.

Learn more about the EVOS® FL Imaging System
Explore the entire EVOS® line of imaging systems and accessories

System Highlights
Optics: infinity-corrected optical system, RMS-threaded objectives with 45 mm parfocal distance
Illumination: adjustable intensity LED (>50,000-hour life per light cube)
Light cubes (not included): broad selection of patented standard and specialty light cubes
Common light cubes include: DAPI (Ex 360 nm/Em 447 nm), GFP (Ex 470 nm/Em 525 nm), RFP (Ex 530 nm/Em 593 nm), Texas Red® (Ex 585 nm/Em 624), Cy5 (Ex 628 nm/Em 692 nm)
Contrast methods: fluorescence and transmitted light (brightfield & phase contrast)
Objective turret: 5-position, front-mounted control
Objectives (not included): wide selection of high-quality LWD and coverslip-corrected objectives available
Condenser: 3-position turret with brightfield and phase contrast annuli
Condenser working distance: 60 mm
Stage: mechanical 'glide' stage; X-Y axis fine-positioning controls: 28.3 mm (1.11') per rotation, 110 mm x 110 mm (4.3' x 4.3') range of motion; Z-axis focusing controls: 480 µm/rotation; interchangeable vessel holders are available for most common shapes and sizes
Focus mechanism: coaxial focus knobs with tension control
Course focus: 38 mm/rev
Fine focus: 0.2mm/rev, precision 0.002 mm
LCD display: 15-inch color, 1024 x 768 pixels, adjustable tilt
Camera: Sony ICX445 monochrome CCD, 1/3' 1280 x 960 pixels, 1.3 Megapixels
Image acquisition: onboard microprocessor, built-in software for image acquisition via mouse control
Captured images: 16-bit monochrome TIFF or PNG (12-bit dynamic range); 24-bit color TIFF or PNG; jpeg, bmp, 1280 x 960 pixels
Output ports: 3 USB and 1 DVI
Power supply: AC adapter with country-specific power cords; input 100-240 V, 50-60 Hz; output 12 VDC/4.15 A
Dimensions: operating height = 57.8 cm (22.75 in); storage/transport height = 32.4 cm (12.75 in); depth = 47.0 cm (18.5 in); width = 35.5 cm (14.0 in)
Weight: 15.3 kg (33.7 lbs) 


规格

Color:Transmitted Light
Data Output:BMP Files, JPG Files, PNG Files, TIFF Files
Detection Method:Fluorescent
Dimensions:36 cm (14 in) (W) x 58 cm (23 in) (H) x 47 cm (19 in) (D)
Display Interface:15-inch color monitor, Adjustable tilt
For Use With (Equipment):Fluorescence Microscope
Format:Specific Holder Attachments
Frequency:50⁄60 Hz
Input Voltage:100-240 VAC
Objectives:5 Objective Turret
Product Line:EVOS®
Product Size:1 each
Stage:Mechanical stage with X-Y axis fine-positioning controls
Weight:15.3 kg (33.7 lbs)


规格

Color:Transmitted Light
Data Output:BMP Files, JPG Files, PNG Files, TIFF Files
Detection Method:Fluorescent
Dimensions:36 cm (14 in) (W) x 58 cm (23 in) (H) x 47 cm (19 in) (D)
Display Interface:15-inch color monitor, Adjustable tilt
For Use With (Equipment):Fluorescence Microscope
Format:Specific Holder Attachments
Frequency:50⁄60 Hz
Input Voltage:100-240 VAC
Objectives:5 Objective Turret
Product Line:EVOS®
Product Size:1 each
Stage:Mechanical stage with X-Y axis fine-positioning controls
Weight:15.3 kg (33.7 lbs)


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