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神经干细胞最新研究进展（第5期）
神经干细胞最新研究进展（第5期）
2021 - 01 - 27
2021年3月30日讯/生物谷BIOON/---神经干细胞(neural stem cell)是指存在于神经系统中，具有分化为神经神经元、星形胶质细胞和少突胶质细胞的潜能，从而能够产生大量脑细胞组织，并能进行自我更新，并足以提供大量脑组织细胞的细胞群。需要注意的是，在脑脊髓等所有神经组织中，不同的神经干细胞类型产生的子代细胞种类不同，分布也不同。 神经干细胞的治疗机理是：（i）患病部位组织损伤后释放各种趋化因子，可以吸引神经干细胞聚集到损伤部位，并在局部微环境的作用下分化为不同种类的细胞，修复及补充损伤的神经细胞。由于缺血、缺氧导致的血管内皮细胞、胶质细胞的损伤，使局部通透性增加，另外在多种黏附分子的作用下，神经干细胞可以透过血脑屏障，高浓度的聚集在损伤部位；（ii）神经干细胞可以分泌多种神经营养因子，促进损伤细胞的修复；（iii）神经干细胞可以增强神经突触之间的联系，建立新的神经环路。神经干细胞应用中存在的问题：建立的神经干细胞系绝大多数来源于鼠，而鼠与人之间存在着明显的种属差异；神经干细胞的来源不足；部分移植的神经干细胞发展成脑瘤；神经干细胞转染范围的非选择性表达及转染基因表达的原位调节等等。基于此，小编针对近年来神经干细胞研究取得的进展进行一番盘点，以飨读者。1.Cell Stem Cell：上调核纤层蛋白B1表达让衰老的神经干细胞返老还童doi:10.1016/j.stem...
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Science：重磅！发现重写创伤记忆的神经元
Science：重磅！发现重写创伤记忆的神经元
2018 - 06 - 22
对创伤经历的回忆会导致精神健康问题，如创伤后应激障碍（PTSD），这会破坏一个人的生活。据估计，当前将近三分之一的人会在他们生命中的某个时刻遭受恐惧或应激相关的障碍。如今，一项新的研究在细胞水平展示了一种疗法如何能够治疗长期的创伤记忆。相关研究结果发表在2018年6月15日的Science期刊上，论文标题为“Reactivation of recall-induced neurons contributes to remote fear memory attenuation”。论文通信作者、瑞士洛桑联邦理工学院（EPFL）教授Johannes Gräff说，“我们的研究结果首次揭示了让成功治疗创伤记忆变得可能的过程。” 在治疗创伤记忆领域，对恐惧衰减（fear attenuation）是否涉及通过新的安全记忆痕迹（memory trace of safety）或将原始的恐惧记忆痕迹（memory trace of fear）重写为安全记忆痕迹来抑制原始的恐惧记忆痕迹，人们长期以来争论不止。图片来自EPFL / Gräff Group。这种争论的一部分与我们总体上还不能完全理解神经元如何存储记忆的事实相关。虽然这项研究取得的新发现不能排除这种抑制机制，但是它们首次证实了重写创伤记忆在治疗创伤记忆中的重要性。这个领域的研究重点在于理解大脑减少创伤记忆的能力...
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都是 “反疫苗运动” 惹的祸
都是 “反疫苗运动” 惹的祸
2019 - 04 - 12
4 月 9 日，美国纽约市市长比尔 · 德 · 布拉西奥宣布，该市布鲁克林区的威廉斯堡进入紧急状态，让当地民众一时风声鹤唳。是什么导致政府宣布这一近年罕见的公共卫生紧急情况？答案你或许想不到，肇事者居然是为我们熟知的一种疾病——麻疹。卷土重来，美多地暴发麻疹疫情麻疹传染性极强，多见于儿童。我国在 1965 年后进行针对性疫苗接种的推广，这种疾病发病率逐渐减少。在美国，本已消失的麻疹病例在近些年时有出现，今年在个别地区更是呈大暴发之势。美国疾病控制中心（CDC）数据显示，截至 4 月 4 日，美国 19 个州统计共出现 465 个麻疹病例，成为 2000 年以来疫情第二严重年份（2014 年全美病例达 667 例）。而纽约的布鲁克林则成为重灾区，仅威廉斯堡这一社区从去年 10 月至今年 4 月 8 日就有 228 例确诊病例。除纽约市外，纽约州、新泽西州、华盛顿州、密歇根州以及加州等多个地区出现了 3 例以上的麻疹病例。而 CDC 将一地区出现 3 例以上麻疹病例定义为疫情暴发。一时间，麻疹疫情成为美国公共卫生领域最受关注的话题。推波助澜，“反疫苗运动” 难辞其咎CDC 认为，美国的麻疹疫情与从以色列、乌克兰和菲律宾等国来美旅客有关，这些国家正在暴发大规模麻疹疫情。而对于纽约市布鲁克林区来说，麻疹疫情的暴发则要归咎于人们的错误认知。一场愈演愈烈的 “反疫苗运动”，...
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EVOS™ Vessel Holder, two 25-cm T-flasks
产品名称： EVOS™ Vessel Holder, two 25-cm T-flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...
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EVOS™ Vessel Holder, one 100-mm Petri dish
产品名称： EVOS™ Vessel Holder, one 100-mm Petri dish
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ Vessel Holder, two 60-mm Petri dishes
产品名称： EVOS™ Vessel Holder, two 60-mm Petri dishes
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
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EVOS™ Vessel Holder, four 35-mm Petri dishes
产品名称： EVOS™ Vessel Holder, four 35-mm Petri dishes
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...
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EVOS™ Vessel Holder, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ 4X Objective, fluorite, LWD, phase-contrast
产品名称： EVOS™ 4X Objective, fluorite, LWD, phase-contrast
型号：
时间： 2019 - 04 - 12
描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...
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EVOS™ Light Cube, Cy™5
产品名称： EVOS™ Light Cube, Cy™5
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...
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EVOS™ Light Cube, RFP
产品名称： EVOS™ Light Cube, RFP
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...
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EVOS™ Light Cube, GFP
产品名称： EVOS™ Light Cube, GFP
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The GFP light cube is ideal for use with Alexa Fluor® ...
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EVOS™ Light Cube, DAPI
产品名称： EVOS™ Light Cube, DAPI
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The DAPI light cube is ideal for use with Acridine, Alexa F...
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EVOS™ Power Cord, Type I (Australia)
产品名称： EVOS™ Power Cord, Type I (Australia)
型号：
时间： 2019 - 04 - 12
描述This power cord is for use with EVOS® XL, FL , FL Color, and FL Auto systems in countries with Type I power plugs. The Type I electrical plug is mainly used in Australia and New Zealand, but is also used in China and parts of Asia, South America, and Africa.
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EVOS™ 20X Objective, achromat, LWD, phase-contrast
产品名称： EVOS™ 20X Objective, achromat, LWD, phase-contrast
型号：
时间： 2019 - 04 - 11
描述This achromat objective is ideal for general applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnificati...
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