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肌肉干细胞研究最新进展（第4期）
肌肉干细胞研究最新进展（第4期）
2021 - 04 - 01
2021年3月29日讯/生物谷BIOON/---肌肉干细胞可发育分化为成肌细胞(myoblasts)，后者可互相融合成为多核的肌纤维，形成骨骼肌最基本的结构。人类胚胎和成人体内都存在肌肉干细胞。胚胎和胎儿的肌肉干细胞增殖使得肌肉组织发展；成年人体内的肌肉干细胞亦被称为卫星细胞，处于休眠状态，沿着肌肉纤维而分布。在经过强烈运动或是受到外界伤害之后，成人的肌肉干细胞会被激活并开始自我增殖，从而增加或是恢复成人的肌肉组织。对于老年人，肌肉干细胞不再具有自我复制的活性，从而表现为肌肉组织的萎缩。小编针对近年来肌肉干细胞研究取得的进展进行一番盘点，以飨读者。1.Nature子刊：揭示一种化学物混合物可产生大量的肌肉干细胞doi:10.1038/s41551-021-00696-y在一项新的研究中，来自美国加州大学洛杉矶分校的研究人员鉴定出一种化学物混合物，它能够大量地产生可以自我更新并可产生所有类型骨骼肌细胞的肌肉干细胞。这一进展可能导致开发基于干细胞的疗法，以治疗因受伤、年龄或疾病而导致的肌肉损失或损伤。相关研究结果近期发表在Nature Biomedical Engineering期刊上，论文标题为“Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in...
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两篇Cell重磅！三种基因告诉你人脑何以为人脑
两篇Cell重磅！三种基因告诉你人脑何以为人脑
2018 - 06 - 29
Cell杂志发文称，科学家已发现3个几乎相同的基因可以帮助解释人类早期祖先的0.5升灰质是如何成为1.4升器官的，这一进化使得人类这一物种是如此成功和独特。另外，新发现的基因帮助解释了大脑发育有时是如何出错并导致神经系统紊乱的。DOI: https://doi.org/10.1016/j.cell.2018.03.051这一新发现的明星家族——NOTCH2NL，在大脑皮质发育过程中表达，负责促进神经祖细胞更新，从而产生更多的神经元。NOTCH2NL本身是NOTCH基因家族的一个分支，后者负责调控所有生物（从过引导鲸鱼）的发育时间。但是，5月31日发表在Cell上的两项研究显示，在最近的进化史中，发生了一系列“基因事故”，在人类身上产生了4个非常密切相关的NOTCH2NL基因。“这些基因是一个古老的发育基因的后代，在进化过程中不断复制和改变，从而加入与人脑扩大有关的DNA名单中。”耶鲁大学进化基因组学家James Noonan说，“它们会增加脑组织中潜在神经细胞的数量这些新蛋白质可能会以非常强大的方式改变脑部发育中的重要途径。”论文一：人类独有的NOTCH2NL在猿的祖先中，NOTCH2的复制产生了一个非功能性的NOTCH2NL (gray)。修复和后来的基因复制产生了多个拷贝。(GRAPHIC) V. ALTOUNIAN/SCIENCE; (DATA) FIDDES ET AL.,...
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RNA 干扰被发现是人类神经早期发育的 “保护伞”
RNA 干扰被发现是人类神经早期发育的 “保护伞”
2019 - 04 - 20
新华社武汉 4 月 19 日电（记者谭元斌）我国科研人员的一项最新研究表明，人神经前体细胞可以利用 RNA 干扰抗病毒免疫抵抗寨卡病毒感染。这一研究首次发现 RNA 干扰抗病毒免疫机制在人类神经发育过程中的关键作用，相关研究成果近期以封面文章的形式发表在国际知名期刊《细胞研究》上。在这项研究中，中国科学院武汉病毒研究所、军事科学院军事医学研究院、中国科学院动物研究所科研人员组成的联合研究团队，从寨卡病毒对人神经前体细胞独特的感染嗜性入手，首次在病毒自然感染的条件下证明了 RNA 干扰抗病毒免疫在人类细胞中的重要抗病毒作用。专家认为，人神经前体细胞中 RNA 干扰抗病毒通路的存在，为相应抗病毒药物的研发提供了新的靶标。他们发现，临床上广泛使用的 “老药” 依诺沙星能增强人神经前体细胞内 RNA 干扰的活性，在人神经前体细胞及由此分化产生的类脑器官中显示出非常高效的抗病毒作用，阻断了寨卡病毒感染所致的小头畸形表型。在同期的《细胞研究》上，刊登了世界著名病毒学家史佩勇教授对这项研究成果的评述文章。他在文章中评价这是 RNA 干扰研究的一项十分重要的进展。据中国科学院武汉病毒研究所专家介绍，RNA 干扰是生物体内普遍存在的一种古老的生物学现象，对控制生物体内基因表达起关键作用。而其作为人类中的一种重要抗病毒免疫机制，则是近年来由我国及欧美科学家的一系列研究共同发现。同时，RNA 干扰作为一...
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EVOS™ Vessel Holder, two 25-cm T-flasks
产品名称： EVOS™ Vessel Holder, two 25-cm T-flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...
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EVOS™ Vessel Holder, one 100-mm Petri dish
产品名称： EVOS™ Vessel Holder, one 100-mm Petri dish
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ Vessel Holder, two 60-mm Petri dishes
产品名称： EVOS™ Vessel Holder, two 60-mm Petri dishes
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
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EVOS™ Vessel Holder, four 35-mm Petri dishes
产品名称： EVOS™ Vessel Holder, four 35-mm Petri dishes
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...
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EVOS™ Vessel Holder, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ 4X Objective, fluorite, LWD, phase-contrast
产品名称： EVOS™ 4X Objective, fluorite, LWD, phase-contrast
型号：
时间： 2019 - 04 - 12
描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...
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EVOS™ Light Cube, Cy™5
产品名称： EVOS™ Light Cube, Cy™5
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...
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EVOS™ Light Cube, RFP
产品名称： EVOS™ Light Cube, RFP
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...
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EVOS™ Light Cube, GFP
产品名称： EVOS™ Light Cube, GFP
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The GFP light cube is ideal for use with Alexa Fluor® ...
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EVOS™ Light Cube, DAPI
产品名称： EVOS™ Light Cube, DAPI
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The DAPI light cube is ideal for use with Acridine, Alexa F...
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EVOS™ Power Cord, Type I (Australia)
产品名称： EVOS™ Power Cord, Type I (Australia)
型号：
时间： 2019 - 04 - 12
描述This power cord is for use with EVOS® XL, FL , FL Color, and FL Auto systems in countries with Type I power plugs. The Type I electrical plug is mainly used in Australia and New Zealand, but is also used in China and parts of Asia, South America, and Africa.
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EVOS™ 20X Objective, achromat, LWD, phase-contrast
产品名称： EVOS™ 20X Objective, achromat, LWD, phase-contrast
型号：
时间： 2019 - 04 - 11
描述This achromat objective is ideal for general applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnificati...
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