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1
2019 - 02 - 28
据新华社电 瑞典哥德堡大学一项新研究表明,中年时期积极进行体力和脑力活动,有助降低罹患老年痴呆症的风险。哥德堡大学研究人员近日发表在美国《神经学》杂志上的一篇论文说,他们对 800 名瑞典女性进行了长达 44 年的跟踪调查,这些女性刚参与研究时平均年龄为 47 岁,并被按照参与脑力和体力活动的情况打分及分组。该研究中,脑力活动包括阅读和写作等智力活动、听音乐会和参加合唱团等艺术活动以及做针线活等手工活动。44% 的参与者被划分到脑力活动水平较低的低分组;56% 的人被划分到高分组。对体力活动,则分为活跃组和不活跃组。每周进行 4 小时以上步行、骑单车等低强度运动,或每周有规律地进行高强度运动如跑步、游泳等,或参与竞技运动,被划分到活跃组。按此标准,17% 的参与者被视为不活跃;82% 的人被视为活跃。研究发现,在排除了高血压、抽烟和糖尿病等风险因素后,脑力活动高分组女性比低分组女性罹患阿尔茨海默病的风险低 46%,罹患老年痴呆症的总体风险低 34%;而体力活动活跃组的女性比不活跃组女性罹患血管性痴呆症的风险低 52%,罹患混合型痴呆症的风险低 56%。摘自:生物360来源:中国科学报
2
2019 - 07 - 12
大脑每天接收的来自客观世界的感觉信息纷繁复杂,大脑对这些刺激进行分类后,人们才有感知判断。那么大脑是如何开展这项工作的呢?中科院脑科学与智能技术卓越创新中心(中科院神经科学研究所)研究员徐宁龙团队揭示了其中的奥秘,解析了大脑对感觉信息进行范畴化的皮层神经元群体运算机制。相关成果日前在线发表于《神经元》。大脑每天接收海量的来自客观世界的感觉信息,能够形成的概念和采取的行动却数目有限,为形成有意义的认知来指导行为,大脑需要对这些信息进行高效的组织管理,其中最基本的过程就是范畴化——简言之,就是分类。神经科学家本世纪初开启了信息分类和感知觉范畴化神经机制研究的新领域,但以往研究侧重神经运算的结果,对于感觉信息怎样被转化为离散的类别信息这一神经运算过程,并没有明确答案。本研究中,研究人员在小鼠中建立了一个基于听觉的分类抉择行为范式,结合活体双光子成像技术,解析了对感觉信息进行范畴化的皮层神经元群体运算机制。徐宁龙介绍,听到声音,经过训练的小鼠大脑中的一类神经元表现出对声音类别的特异性反应,将不同频率的纯音归类到 “高音” 或“低音”范畴。在高低音临界点的分类中,小鼠会“纠结”。这时大脑中的另一类神经元,表现出对类别边界频率声音的“选择性反应”,协助小鼠进行判断和分类。如果小鼠没有被要求完成分类任务,这类神经元选择性反应则“难觅踪迹”。研究表明,在听觉皮层中存在范畴抉择相关的单细胞反应,听觉...
3
2020 - 02 - 14
2020年2月12日讯 /生物谷BIOON /--弗朗西斯克里克研究所(Francis Crick Institute)的研究人员发现了一种控制组织结构的关键机制,这种机制可能有助于识别使癌细胞更难扩散的药物。这项发表在《Nature Materials》上的研究解释了导致组织结构变化的机制。这些研究利用实验生物学和计算生物学,确定了细胞之间的碰撞如何帮助创建不同的组织结构。其中一些结构有助于癌症扩散,作者还发现了抑制这一过程的药物。图片来源:Nature Materials体内的所有组织都含有维持其结构的蛋白质支架。这种支架会随着人的衰老而退化,导致出现皱纹等衰老迹象。癌细胞可以破坏支架的形状,从而创造出一个组织结构,并通过各种途径从肿瘤进入周围组织。癌细胞利用这些超级高速公路沿着它们扩散到新的区域。然而,虽然我们知道这些超级高速公路与癌症的发展有关,但对于控制这些组织结构形成的机制却知之甚少。克里克肿瘤细胞生物学实验室的研究科学家Danielle Park说:'这些超级高速公路为癌细胞走出肿瘤并在组织中更广泛地扩散提供了道路,这可能会给病人带来灾难性的后果。通过更多地了解这种结构是如何形成的,我们就能找到阻止它的方法,并对癌细胞的扩散设置障碍。'通过将实验室实验的观察结果与该团队开发的新计算机模型的结果相结合,研究人员发现了组织支架的形状如何受到其与帮助构建支架...
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产品名称:

EVOS™ M7000 Imaging System

上市日期: 2019-04-15
产品类别: EVOS

规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


  • 产品描述
  • 产品功能
  • 产品参数

描述

The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-stacks in scan mode, and a superb optomechanical design enable the generation of publication-quality images and data with just a few clicks when and where needed.

The EVOS M7000 Imaging System offers these advantages:
• Outstanding image quality and versatility with a 5-position objective turret, 4-color LED fluorescence and transmitted light channels, and 3.2 MP CMOS color and B/W cameras
• Exceptional usability with fully automated X/Y scanning stage, autofocus, and acquisition routines
• High-speed image acquisition coupled with multi-position well scanning, and Z-stack and tile-stitch options lend power and flexibility to your data generation
• Fully integrated time-lapse live cell imaging using the optional EVOS Onstage Incubator for precise control of temperature, gases for normoxic or hypoxic conditions, and humidity
• Powerful image analysis capabilities for cell segmentation and quantification with the optional Celleste™ Image Analysis Software

Fully automated imaging system
The EVOS M7000 system combines and integrates precision components with a unique modern design functionality that enables high-quality automated fluorescence imaging anywhere with unprecedented workflow efficiency. Full automation of the precision X/Y-stage movement; changing of the 4 LED fluorescent light cubes, 5-position objective turret, focus, and exposure; and switching of the dual camera make the EVOS M7000 system an exceptional platform for a variety of demanding imaging applications. Through the intuitive acquisition interface, you can program the EVOS M7000 system to run well-plate scanning, time lapse experiments, and tile-stitch/montage area scans in Z-stack and/or time-lapse modes in your vessel of choice. For live cell imaging over multiple hours or days, the optional EVOS Onstage Incubator, which functions as an environmental chamber on top of the microscope stage, is operated seamlessly from within the instrument interface. The EVOS M7000 system is compatible with all accessories for the predecessor EVOS FL Auto imaging system.

Versatile and highly configurable
With a 5-position objective turret and the ability to simultaneous acquire images in four fluorescence channels plus transmitted light, the optical system can be easily configured to meet your needs. Choose from our broad range of high quality coverslip-corrected and long-working-distance objectives for use with plastic vessels or glass sides. Available from 1.25X to 100X magnification in achromat, fluorite, or apochromat models, together with over twenty LED light cubes, the sample imaging options are limitless. Dual monochrome and color high-sensitivity dual CMOS cameras enable seamless imaging of both fluorescent and chromogenically stained samples. Interchangeable vessel holders accommodate most vessel types and sizes, including slides, multi-well plates, culture flasks, and Petri dishes, and afford precise control and sample alignment by the automated stage. The vessel creation wizard in the user interface enables creation of profiles for custom sample vessels.

Powerful software
The EVOS M7000 software presents users with an extensive suite of tools for acquisition, visualization, and analysis. The user interface was designed with a strong emphasis on usability, including an option to view samples in a single field mode (Field View) or in a window that covers a much larger area (Area View). By using a zoom function, the Area View size can be adjusted. A user can explore a large sample area at low magnification, define regions of interest, and then seamlessly transition to the Scan function in Automate Mode and execute an area scan at higher magnification.

The enhanced power of the EVOS M7000 system enables more demanding automated acquisition routines like area scanning in time lapse and Z-stacks in scan mode to be performed. Visualization capabilities include multi-field image viewing gallery, mosaic tiling and tile stitching options, Z-stack visualization, and a video recording and movie maker/editor for time lapse sequences. The EVOS M7000 system is fully compatible with the EVOS Onstage Incubator environmental chamber for control of temperature, gases, and humidity. With the ability generate both hypoxic and normoxic conditions, it is possible to study live cells over extended periods with highly flexible time lapse automation routines.

For users needing more powerful image analysis capabilities, images acquired on the EVOS M7000 system can be analyzed directly using the optional Celleste Image Analysis Software. Celleste software offers powerful tools for image segmentation and classification that can be applied to a range of cell analysis applications for counting and measuring intensity, area, and shape changes over time, and more.

Smart LED illumination technology
All EVOS fluorescence imaging systems utilize our proprietary LED light cubes. This light engine outputs remarkable intensity over a short light path and delivers incomparable fluorophore excitation. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels to the sample and experimental conditions to minimize the risk of photo-toxicity and photo-bleaching in time-lapse studies. Hard-coated filters give sharper edges and significantly higher transmission efficiencies than traditional soft-coated filters.

Easy to use and reliable
The EVOS M7000 Imaging System is powerful, yet offers the simplicity of plug-and-play. Like other EVOS systems, it requires no warm-up or cool-down periods. The LED light source guarantees exceptional stability and durability, so you can turn the unit on and off whenever you need to image a sample. The environmentally safe, mercury-free LED bulbs are rated for >50,000 hours, compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. The long lifetime and low energy consumption translate into significantly lower operating costs compared to instruments with conventional light sources. The EVOS M7000 system is powered by an external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope. Whether acquiring single images or setting up automated routines, the EVOS M7000 system is remarkably easy to use and run. The 1920 x 1080 pixel resolution 23' LCD touch screen monitor enables “finger swipes” to expand or zoom in on images, and moving between microwell plate wells is done by a single touch. Operation is also also fully controllable via mouse.

The EVOS imaging systems are built from the ground up to maximize performance and optimize workflow. You will be astonished at how easy it is to operate and amazed at how extraordinary your images look on-screen.

Explore the entire EVOS line of imaging systems, accessories, and offers ›

System and hardware specifications
Optics: infinity‐corrected optical system; RMS‐threaded objectives with 45-mm parfocal distance
Imaging mode: fluorescence, brightfield, color brightfield, and phase contrast
Illumination: five position chamber for 4 fluorescence light cubes plus brightfield; light cubes with integrated hard coated filter set and LED light source with >50,000 hour life; broad selection of standard and specialty light cubes
Imaging methods: single color, multi-color, area scan with montage or tile-stitch, time lapse, Z-stacking, movie capture
Objective capacity: 5‐position turret
Objectives (not included): wide selection of high‐quality LWD and coverslip‐corrected objectives
Condenser: 60-mm long working distance condenser, 4 position turret with a clear aperture and 3 phase annuli
Stage: motorized X/Y scanning stage; travel range 120 mm x 80 mm with sub‐micron resolution, drop‐in inserts to receive vessel holders and lock down holders to fix sample in place during long scans
Focus mechanism: automated focus mechanism with sub‐micron resolution
LCD display: 23' high‐resolution touch screen color monitor (also fully controllable via mouse); 1920 x 1080 pixel resolution
Cameras: high-sensitivity 3.2 MP (2048 x 1536) monochrome CMOS sensor with 3.45 µm pixel resolution; high-sensitivity 3.2 MP (2048 x 1536) color CMOS sensor with 3.45 µm pixel resolution
Computer: external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope
Captured images: 16‐bit RAW monochrome: TIFF, PNG; 8-bit: TIFF, PNG, JPG; movies and time‐lapse: AVI, WMV
Output ports: Computer: 1 x USB 3.1 Gen 2 Type-C; 5 x USB 3.1 Gen 1 Type-A; 4 x USB 2.0 Type-A; 1 Serial; 2 Display Ports 1.2; 1 RJ-45; 2 PS/2; 1 UAJ; 1 Line-out
Networking capability: connection through Windows/SMB network via an Ethernet cable connection
Power supply: 24 V AC adapter with country‐specific power cords
Dimensions (L x W x H): 18 x 14 x 13 inches (457 x 330 x 356 mm)
Weight: 16/35 (kg/lb)


规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


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