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1
2018 - 06 - 22
对创伤经历的回忆会导致精神健康问题,如创伤后应激障碍(PTSD),这会破坏一个人的生活。据估计,当前将近三分之一的人会在他们生命中的某个时刻遭受恐惧或应激相关的障碍。如今,一项新的研究在细胞水平展示了一种疗法如何能够治疗长期的创伤记忆。相关研究结果发表在2018年6月15日的Science期刊上,论文标题为“Reactivation of recall-induced neurons contributes to remote fear memory attenuation”。论文通信作者、瑞士洛桑联邦理工学院(EPFL)教授Johannes Gräff说,“我们的研究结果首次揭示了让成功治疗创伤记忆变得可能的过程。” 在治疗创伤记忆领域,对恐惧衰减(fear attenuation)是否涉及通过新的安全记忆痕迹(memory trace of safety)或将原始的恐惧记忆痕迹(memory trace of fear)重写为安全记忆痕迹来抑制原始的恐惧记忆痕迹,人们长期以来争论不止。图片来自EPFL / Gräff Group。这种争论的一部分与我们总体上还不能完全理解神经元如何存储记忆的事实相关。虽然这项研究取得的新发现不能排除这种抑制机制,但是它们首次证实了重写创伤记忆在治疗创伤记忆中的重要性。这个领域的研究重点在于理解大脑减少创伤记忆的能力...
2
2019 - 04 - 12
4 月 9 日,美国纽约市市长比尔 · 德 · 布拉西奥宣布,该市布鲁克林区的威廉斯堡进入紧急状态,让当地民众一时风声鹤唳。是什么导致政府宣布这一近年罕见的公共卫生紧急情况?答案你或许想不到,肇事者居然是为我们熟知的一种疾病——麻疹。卷土重来,美多地暴发麻疹疫情麻疹传染性极强,多见于儿童。我国在 1965 年后进行针对性疫苗接种的推广,这种疾病发病率逐渐减少。在美国,本已消失的麻疹病例在近些年时有出现,今年在个别地区更是呈大暴发之势。美国疾病控制中心(CDC)数据显示,截至 4 月 4 日,美国 19 个州统计共出现 465 个麻疹病例,成为 2000 年以来疫情第二严重年份(2014 年全美病例达 667 例)。而纽约的布鲁克林则成为重灾区,仅威廉斯堡这一社区从去年 10 月至今年 4 月 8 日就有 228 例确诊病例。除纽约市外,纽约州、新泽西州、华盛顿州、密歇根州以及加州等多个地区出现了 3 例以上的麻疹病例。而 CDC 将一地区出现 3 例以上麻疹病例定义为疫情暴发。一时间,麻疹疫情成为美国公共卫生领域最受关注的话题。推波助澜,“反疫苗运动” 难辞其咎CDC 认为,美国的麻疹疫情与从以色列、乌克兰和菲律宾等国来美旅客有关,这些国家正在暴发大规模麻疹疫情。而对于纽约市布鲁克林区来说,麻疹疫情的暴发则要归咎于人们的错误认知。一场愈演愈烈的 “反疫苗运动”,...
3
2019 - 08 - 23
2019年8月23日讯 /生物谷BIOON /——2019年6月,欧洲大部分地区遭遇了早期热浪,法国的气温达到了创纪录的46摄氏度(115华氏度)。热浪的特点是在几天几夜持续高温。它们对我们的日常生活有重要的影响--我们感到过热和疲劳。当热浪来袭时,许多政府会启动一项'热行动计划',建议受影响的人多喝水,避免剧烈运动,保持凉爽。如果不这样做,就有中暑的风险,而中暑有可能危及生命。但是,人体究竟是如何应对如此极端的温度的呢?为什么高温如此危险呢?哪些器官受到影响,什么时候情况会变得更糟?图片来源:http://cn.bing.com保持凉爽人体的核心温度通常在36到38摄氏度之间波动(97到99华氏度)。在这个温度范围内,生化反应可以正常进行,这对细胞和器官的正常功能至关重要。人类的身体也能很好地应对各种可能威胁其核心温度的环境条件。当核心温度偏离正常范围时,身体就会启动生理反应,使温度恢复正常。这种温度调节反应相当于你家的恒温器;一旦内部温度偏离理想温度,加热或冷却系统就会被激活,回到理想温度。在人体中,这个恒温器位于我们大脑的底部,一个叫做下丘脑的区域。位于我们皮肤、肌肉和其他器官的温度传感器提供的信息被分析,必要时,启动生理反应。对温度升高的第一个也是最重要的反应是通过我们身体的皮肤和四肢,如手和脚散热。我们开始产生汗液,汗液会在皮肤上蒸发,在这个过程中散热。这...
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总部地址:北京市海淀区西二旗西路热力公司院内泰禾文化园二层
产品名称:

EVOS™ M7000 Imaging System

上市日期: 2019-04-15
产品类别: EVOS

规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


  • 产品描述
  • 产品功能
  • 产品参数

描述

The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-stacks in scan mode, and a superb optomechanical design enable the generation of publication-quality images and data with just a few clicks when and where needed.

The EVOS M7000 Imaging System offers these advantages:
• Outstanding image quality and versatility with a 5-position objective turret, 4-color LED fluorescence and transmitted light channels, and 3.2 MP CMOS color and B/W cameras
• Exceptional usability with fully automated X/Y scanning stage, autofocus, and acquisition routines
• High-speed image acquisition coupled with multi-position well scanning, and Z-stack and tile-stitch options lend power and flexibility to your data generation
• Fully integrated time-lapse live cell imaging using the optional EVOS Onstage Incubator for precise control of temperature, gases for normoxic or hypoxic conditions, and humidity
• Powerful image analysis capabilities for cell segmentation and quantification with the optional Celleste™ Image Analysis Software

Fully automated imaging system
The EVOS M7000 system combines and integrates precision components with a unique modern design functionality that enables high-quality automated fluorescence imaging anywhere with unprecedented workflow efficiency. Full automation of the precision X/Y-stage movement; changing of the 4 LED fluorescent light cubes, 5-position objective turret, focus, and exposure; and switching of the dual camera make the EVOS M7000 system an exceptional platform for a variety of demanding imaging applications. Through the intuitive acquisition interface, you can program the EVOS M7000 system to run well-plate scanning, time lapse experiments, and tile-stitch/montage area scans in Z-stack and/or time-lapse modes in your vessel of choice. For live cell imaging over multiple hours or days, the optional EVOS Onstage Incubator, which functions as an environmental chamber on top of the microscope stage, is operated seamlessly from within the instrument interface. The EVOS M7000 system is compatible with all accessories for the predecessor EVOS FL Auto imaging system.

Versatile and highly configurable
With a 5-position objective turret and the ability to simultaneous acquire images in four fluorescence channels plus transmitted light, the optical system can be easily configured to meet your needs. Choose from our broad range of high quality coverslip-corrected and long-working-distance objectives for use with plastic vessels or glass sides. Available from 1.25X to 100X magnification in achromat, fluorite, or apochromat models, together with over twenty LED light cubes, the sample imaging options are limitless. Dual monochrome and color high-sensitivity dual CMOS cameras enable seamless imaging of both fluorescent and chromogenically stained samples. Interchangeable vessel holders accommodate most vessel types and sizes, including slides, multi-well plates, culture flasks, and Petri dishes, and afford precise control and sample alignment by the automated stage. The vessel creation wizard in the user interface enables creation of profiles for custom sample vessels.

Powerful software
The EVOS M7000 software presents users with an extensive suite of tools for acquisition, visualization, and analysis. The user interface was designed with a strong emphasis on usability, including an option to view samples in a single field mode (Field View) or in a window that covers a much larger area (Area View). By using a zoom function, the Area View size can be adjusted. A user can explore a large sample area at low magnification, define regions of interest, and then seamlessly transition to the Scan function in Automate Mode and execute an area scan at higher magnification.

The enhanced power of the EVOS M7000 system enables more demanding automated acquisition routines like area scanning in time lapse and Z-stacks in scan mode to be performed. Visualization capabilities include multi-field image viewing gallery, mosaic tiling and tile stitching options, Z-stack visualization, and a video recording and movie maker/editor for time lapse sequences. The EVOS M7000 system is fully compatible with the EVOS Onstage Incubator environmental chamber for control of temperature, gases, and humidity. With the ability generate both hypoxic and normoxic conditions, it is possible to study live cells over extended periods with highly flexible time lapse automation routines.

For users needing more powerful image analysis capabilities, images acquired on the EVOS M7000 system can be analyzed directly using the optional Celleste Image Analysis Software. Celleste software offers powerful tools for image segmentation and classification that can be applied to a range of cell analysis applications for counting and measuring intensity, area, and shape changes over time, and more.

Smart LED illumination technology
All EVOS fluorescence imaging systems utilize our proprietary LED light cubes. This light engine outputs remarkable intensity over a short light path and delivers incomparable fluorophore excitation. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels to the sample and experimental conditions to minimize the risk of photo-toxicity and photo-bleaching in time-lapse studies. Hard-coated filters give sharper edges and significantly higher transmission efficiencies than traditional soft-coated filters.

Easy to use and reliable
The EVOS M7000 Imaging System is powerful, yet offers the simplicity of plug-and-play. Like other EVOS systems, it requires no warm-up or cool-down periods. The LED light source guarantees exceptional stability and durability, so you can turn the unit on and off whenever you need to image a sample. The environmentally safe, mercury-free LED bulbs are rated for >50,000 hours, compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. The long lifetime and low energy consumption translate into significantly lower operating costs compared to instruments with conventional light sources. The EVOS M7000 system is powered by an external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope. Whether acquiring single images or setting up automated routines, the EVOS M7000 system is remarkably easy to use and run. The 1920 x 1080 pixel resolution 23' LCD touch screen monitor enables “finger swipes” to expand or zoom in on images, and moving between microwell plate wells is done by a single touch. Operation is also also fully controllable via mouse.

The EVOS imaging systems are built from the ground up to maximize performance and optimize workflow. You will be astonished at how easy it is to operate and amazed at how extraordinary your images look on-screen.

Explore the entire EVOS line of imaging systems, accessories, and offers ›

System and hardware specifications
Optics: infinity‐corrected optical system; RMS‐threaded objectives with 45-mm parfocal distance
Imaging mode: fluorescence, brightfield, color brightfield, and phase contrast
Illumination: five position chamber for 4 fluorescence light cubes plus brightfield; light cubes with integrated hard coated filter set and LED light source with >50,000 hour life; broad selection of standard and specialty light cubes
Imaging methods: single color, multi-color, area scan with montage or tile-stitch, time lapse, Z-stacking, movie capture
Objective capacity: 5‐position turret
Objectives (not included): wide selection of high‐quality LWD and coverslip‐corrected objectives
Condenser: 60-mm long working distance condenser, 4 position turret with a clear aperture and 3 phase annuli
Stage: motorized X/Y scanning stage; travel range 120 mm x 80 mm with sub‐micron resolution, drop‐in inserts to receive vessel holders and lock down holders to fix sample in place during long scans
Focus mechanism: automated focus mechanism with sub‐micron resolution
LCD display: 23' high‐resolution touch screen color monitor (also fully controllable via mouse); 1920 x 1080 pixel resolution
Cameras: high-sensitivity 3.2 MP (2048 x 1536) monochrome CMOS sensor with 3.45 µm pixel resolution; high-sensitivity 3.2 MP (2048 x 1536) color CMOS sensor with 3.45 µm pixel resolution
Computer: external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope
Captured images: 16‐bit RAW monochrome: TIFF, PNG; 8-bit: TIFF, PNG, JPG; movies and time‐lapse: AVI, WMV
Output ports: Computer: 1 x USB 3.1 Gen 2 Type-C; 5 x USB 3.1 Gen 1 Type-A; 4 x USB 2.0 Type-A; 1 Serial; 2 Display Ports 1.2; 1 RJ-45; 2 PS/2; 1 UAJ; 1 Line-out
Networking capability: connection through Windows/SMB network via an Ethernet cable connection
Power supply: 24 V AC adapter with country‐specific power cords
Dimensions (L x W x H): 18 x 14 x 13 inches (457 x 330 x 356 mm)
Weight: 16/35 (kg/lb)


规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


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