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2019 - 11 - 01
据《世界阿尔茨海默症2018年报告》显示,每3秒钟,全球就有一位痴呆症患者产生。全球目前至少有5000万的痴呆患者。在中国,目前约有1000万阿尔茨海默症患者,预计到2050年,患者数将超过4000万人,比加拿大的总人口还要多。因此,理解这种疾病的发病原因比以往任何时候都更加迫切。此前有许多研究已经发现了一些增加罹患痴呆症风险的因素。有些因素是无法阻止的,如衰老。然而,其他潜在风险因素是有可能避免的,比如吸烟与饮酒。确定这些风险因素非常重要,因为它们有助于预防或延缓痴呆症的发生。近日,发表在JAMA Network Open上的一篇研究,来自美国哈佛大学T.H.Chan公共卫生学院的研究人员设计了一项研究以寻找痴呆症与饮酒之间的联系。尽管已有关于饮酒与痴呆症的相关研究,但研究的科学性还有所欠缺。例如,在之前的一项研究中,研究人员计算了每年的日平均饮酒量。但是以这种方式计算的每日平均饮酒量会忽略酒精含量和饮酒频率的细微差别。这一点非常重要。例如,每周有一天喝7杯啤酒可能会产生不同于每晚喝1杯啤酒的影响,尽管消耗的酒精量是一样的。另一项研究的作者得出结论,中年酗酒会增加患痴呆症的风险。然而,目前还不清楚经常性的少量饮酒是否有同样的影响。其他关于酒精、痴呆症风险、载脂蛋白E4(APOE E4)之间关联的研究使这一问题的答案更加复杂。这种基因变异与患阿尔茨海默症的风险增加有关。较早的一项研...
2
2019 - 07 - 12
大脑每天接收的来自客观世界的感觉信息纷繁复杂,大脑对这些刺激进行分类后,人们才有感知判断。那么大脑是如何开展这项工作的呢?中科院脑科学与智能技术卓越创新中心(中科院神经科学研究所)研究员徐宁龙团队揭示了其中的奥秘,解析了大脑对感觉信息进行范畴化的皮层神经元群体运算机制。相关成果日前在线发表于《神经元》。大脑每天接收海量的来自客观世界的感觉信息,能够形成的概念和采取的行动却数目有限,为形成有意义的认知来指导行为,大脑需要对这些信息进行高效的组织管理,其中最基本的过程就是范畴化——简言之,就是分类。神经科学家本世纪初开启了信息分类和感知觉范畴化神经机制研究的新领域,但以往研究侧重神经运算的结果,对于感觉信息怎样被转化为离散的类别信息这一神经运算过程,并没有明确答案。本研究中,研究人员在小鼠中建立了一个基于听觉的分类抉择行为范式,结合活体双光子成像技术,解析了对感觉信息进行范畴化的皮层神经元群体运算机制。徐宁龙介绍,听到声音,经过训练的小鼠大脑中的一类神经元表现出对声音类别的特异性反应,将不同频率的纯音归类到 “高音” 或“低音”范畴。在高低音临界点的分类中,小鼠会“纠结”。这时大脑中的另一类神经元,表现出对类别边界频率声音的“选择性反应”,协助小鼠进行判断和分类。如果小鼠没有被要求完成分类任务,这类神经元选择性反应则“难觅踪迹”。研究表明,在听觉皮层中存在范畴抉择相关的单细胞反应,听觉...
3
2019 - 06 - 24
2019年6月24日讯 /生物谷BIOON /——普林斯顿大学的Bonnie Bassler及其同事于近日在《PLOS Pathogens》上发表的一项研究表明,他们已经开发出一种新的突变型受体,这种受体被一种细菌病原体用来进行一种称为群体感应的化学交流过程。正如作者所指出的,突变受体可作为识别抑制群体感应的治疗化合物,以满足迫切的医疗需求。图片来源:McCready AR, et al. (2019)人类病原体绿脓杆菌利用群体感应来协调群体行为,包括生物膜的形成和促感染分子的产生。群体感应是绿脓杆菌成为病原体的关键,它依赖于细胞外信号分子的产生、释放和检测。自诱导因子与受体蛋白结合,共同激活群体感应基因的转录。在这项新研究中,Bassler和他的同事发现、纯化并鉴定了绿脓杆菌RhlR群体感应受体的突变版本,他们称之为RhlR*。值得注意的是,RhlR*不需要它的合作自动诱导器来工作。携带RhlR*的绿脓杆菌能正确形成生物膜,产生毒力因子,感染蛔虫。由于RhlR*不依赖于一种自动诱导剂来发挥作用,以前无法用RhlR进行的生化和遗传分析可以用RhlR*进行。这一发现为绿脓杆菌群体感应元件的工作机制提供了新的见解,其中最引人注目的是PqsE酶,它与RhlR一起控制毒力因子的产生。作者认为,RhlR*是了解绿脓杆菌细胞间通讯和毒性的一个特别有价值的工具,而绿脓杆菌是一种具有高度临床相关性...
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产品名称:

EVOS™ M7000 Imaging System

上市日期: 2019-04-15

规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


产品类别: EVOS
  • 产品描述
  • 产品功能
  • 产品参数

描述

The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-stacks in scan mode, and a superb optomechanical design enable the generation of publication-quality images and data with just a few clicks when and where needed.

The EVOS M7000 Imaging System offers these advantages:
• Outstanding image quality and versatility with a 5-position objective turret, 4-color LED fluorescence and transmitted light channels, and 3.2 MP CMOS color and B/W cameras
• Exceptional usability with fully automated X/Y scanning stage, autofocus, and acquisition routines
• High-speed image acquisition coupled with multi-position well scanning, and Z-stack and tile-stitch options lend power and flexibility to your data generation
• Fully integrated time-lapse live cell imaging using the optional EVOS Onstage Incubator for precise control of temperature, gases for normoxic or hypoxic conditions, and humidity
• Powerful image analysis capabilities for cell segmentation and quantification with the optional Celleste™ Image Analysis Software

Fully automated imaging system
The EVOS M7000 system combines and integrates precision components with a unique modern design functionality that enables high-quality automated fluorescence imaging anywhere with unprecedented workflow efficiency. Full automation of the precision X/Y-stage movement; changing of the 4 LED fluorescent light cubes, 5-position objective turret, focus, and exposure; and switching of the dual camera make the EVOS M7000 system an exceptional platform for a variety of demanding imaging applications. Through the intuitive acquisition interface, you can program the EVOS M7000 system to run well-plate scanning, time lapse experiments, and tile-stitch/montage area scans in Z-stack and/or time-lapse modes in your vessel of choice. For live cell imaging over multiple hours or days, the optional EVOS Onstage Incubator, which functions as an environmental chamber on top of the microscope stage, is operated seamlessly from within the instrument interface. The EVOS M7000 system is compatible with all accessories for the predecessor EVOS FL Auto imaging system.

Versatile and highly configurable
With a 5-position objective turret and the ability to simultaneous acquire images in four fluorescence channels plus transmitted light, the optical system can be easily configured to meet your needs. Choose from our broad range of high quality coverslip-corrected and long-working-distance objectives for use with plastic vessels or glass sides. Available from 1.25X to 100X magnification in achromat, fluorite, or apochromat models, together with over twenty LED light cubes, the sample imaging options are limitless. Dual monochrome and color high-sensitivity dual CMOS cameras enable seamless imaging of both fluorescent and chromogenically stained samples. Interchangeable vessel holders accommodate most vessel types and sizes, including slides, multi-well plates, culture flasks, and Petri dishes, and afford precise control and sample alignment by the automated stage. The vessel creation wizard in the user interface enables creation of profiles for custom sample vessels.

Powerful software
The EVOS M7000 software presents users with an extensive suite of tools for acquisition, visualization, and analysis. The user interface was designed with a strong emphasis on usability, including an option to view samples in a single field mode (Field View) or in a window that covers a much larger area (Area View). By using a zoom function, the Area View size can be adjusted. A user can explore a large sample area at low magnification, define regions of interest, and then seamlessly transition to the Scan function in Automate Mode and execute an area scan at higher magnification.

The enhanced power of the EVOS M7000 system enables more demanding automated acquisition routines like area scanning in time lapse and Z-stacks in scan mode to be performed. Visualization capabilities include multi-field image viewing gallery, mosaic tiling and tile stitching options, Z-stack visualization, and a video recording and movie maker/editor for time lapse sequences. The EVOS M7000 system is fully compatible with the EVOS Onstage Incubator environmental chamber for control of temperature, gases, and humidity. With the ability generate both hypoxic and normoxic conditions, it is possible to study live cells over extended periods with highly flexible time lapse automation routines.

For users needing more powerful image analysis capabilities, images acquired on the EVOS M7000 system can be analyzed directly using the optional Celleste Image Analysis Software. Celleste software offers powerful tools for image segmentation and classification that can be applied to a range of cell analysis applications for counting and measuring intensity, area, and shape changes over time, and more.

Smart LED illumination technology
All EVOS fluorescence imaging systems utilize our proprietary LED light cubes. This light engine outputs remarkable intensity over a short light path and delivers incomparable fluorophore excitation. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels to the sample and experimental conditions to minimize the risk of photo-toxicity and photo-bleaching in time-lapse studies. Hard-coated filters give sharper edges and significantly higher transmission efficiencies than traditional soft-coated filters.

Easy to use and reliable
The EVOS M7000 Imaging System is powerful, yet offers the simplicity of plug-and-play. Like other EVOS systems, it requires no warm-up or cool-down periods. The LED light source guarantees exceptional stability and durability, so you can turn the unit on and off whenever you need to image a sample. The environmentally safe, mercury-free LED bulbs are rated for >50,000 hours, compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. The long lifetime and low energy consumption translate into significantly lower operating costs compared to instruments with conventional light sources. The EVOS M7000 system is powered by an external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope. Whether acquiring single images or setting up automated routines, the EVOS M7000 system is remarkably easy to use and run. The 1920 x 1080 pixel resolution 23' LCD touch screen monitor enables “finger swipes” to expand or zoom in on images, and moving between microwell plate wells is done by a single touch. Operation is also also fully controllable via mouse.

The EVOS imaging systems are built from the ground up to maximize performance and optimize workflow. You will be astonished at how easy it is to operate and amazed at how extraordinary your images look on-screen.

Explore the entire EVOS line of imaging systems, accessories, and offers ›

System and hardware specifications
Optics: infinity‐corrected optical system; RMS‐threaded objectives with 45-mm parfocal distance
Imaging mode: fluorescence, brightfield, color brightfield, and phase contrast
Illumination: five position chamber for 4 fluorescence light cubes plus brightfield; light cubes with integrated hard coated filter set and LED light source with >50,000 hour life; broad selection of standard and specialty light cubes
Imaging methods: single color, multi-color, area scan with montage or tile-stitch, time lapse, Z-stacking, movie capture
Objective capacity: 5‐position turret
Objectives (not included): wide selection of high‐quality LWD and coverslip‐corrected objectives
Condenser: 60-mm long working distance condenser, 4 position turret with a clear aperture and 3 phase annuli
Stage: motorized X/Y scanning stage; travel range 120 mm x 80 mm with sub‐micron resolution, drop‐in inserts to receive vessel holders and lock down holders to fix sample in place during long scans
Focus mechanism: automated focus mechanism with sub‐micron resolution
LCD display: 23' high‐resolution touch screen color monitor (also fully controllable via mouse); 1920 x 1080 pixel resolution
Cameras: high-sensitivity 3.2 MP (2048 x 1536) monochrome CMOS sensor with 3.45 µm pixel resolution; high-sensitivity 3.2 MP (2048 x 1536) color CMOS sensor with 3.45 µm pixel resolution
Computer: external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope
Captured images: 16‐bit RAW monochrome: TIFF, PNG; 8-bit: TIFF, PNG, JPG; movies and time‐lapse: AVI, WMV
Output ports: Computer: 1 x USB 3.1 Gen 2 Type-C; 5 x USB 3.1 Gen 1 Type-A; 4 x USB 2.0 Type-A; 1 Serial; 2 Display Ports 1.2; 1 RJ-45; 2 PS/2; 1 UAJ; 1 Line-out
Networking capability: connection through Windows/SMB network via an Ethernet cable connection
Power supply: 24 V AC adapter with country‐specific power cords
Dimensions (L x W x H): 18 x 14 x 13 inches (457 x 330 x 356 mm)
Weight: 16/35 (kg/lb)


规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


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