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1
2018 - 07 - 05
doi.org/10.1038/s41586-018-0162-7基于20年的深入研究,得克萨斯大学西南医学中心(UT Southwestern)自噬研究中心的主任Beth Levine和团队已经明确:细胞自噬可以延长寿命、改善健康。他们以小鼠为模型发现,自噬水平提高的小鼠寿命更长、更健康。“具体来说,它们的寿命延长了约10%,且不太可能发生与年龄相关的自发性癌症、心脏病等疾病。”Beth Levine表示道。细胞自噬自噬是一种保护机制。当细胞内出现衰老的蛋白质、损坏的细胞器等废弃物时,自噬囊泡会将它们包裹并送至溶酶体中进行降解并得以循环利用,从而确保细胞本身的代谢需求和某些细胞器的更新。细胞自噬过程(图片来源:华威大学)20年前,Beth Levine和同事发现了自噬生物学过程中的一个关键基因beclin 1。他们还发现,自噬对于健康而言必不可少,例如预防神经衰退性疾病、对抗癌症和感染。2003年,Beth Levine团队证实,自噬关联的基因机制对于长寿突变线虫(long-lived mutant roundworms)的寿命延长至关重要。“从那以后,关于‘自噬是延长寿命的关键机制’的观点尤为火热。” Beth Levine解释道,“随着年龄增长,细胞的自噬能力会下降,这可能会导致衰老。”自噬延长寿命然而,一个关键问题仍然没有得到解答:增强自噬水平是否有益于哺乳动物的健康?换句...
2
2019 - 04 - 20
新华社武汉 4 月 19 日电(记者谭元斌)我国科研人员的一项最新研究表明,人神经前体细胞可以利用 RNA 干扰抗病毒免疫抵抗寨卡病毒感染。这一研究首次发现 RNA 干扰抗病毒免疫机制在人类神经发育过程中的关键作用,相关研究成果近期以封面文章的形式发表在国际知名期刊《细胞研究》上。在这项研究中,中国科学院武汉病毒研究所、军事科学院军事医学研究院、中国科学院动物研究所科研人员组成的联合研究团队,从寨卡病毒对人神经前体细胞独特的感染嗜性入手,首次在病毒自然感染的条件下证明了 RNA 干扰抗病毒免疫在人类细胞中的重要抗病毒作用。专家认为,人神经前体细胞中 RNA 干扰抗病毒通路的存在,为相应抗病毒药物的研发提供了新的靶标。他们发现,临床上广泛使用的 “老药” 依诺沙星能增强人神经前体细胞内 RNA 干扰的活性,在人神经前体细胞及由此分化产生的类脑器官中显示出非常高效的抗病毒作用,阻断了寨卡病毒感染所致的小头畸形表型。在同期的《细胞研究》上,刊登了世界著名病毒学家史佩勇教授对这项研究成果的评述文章。他在文章中评价这是 RNA 干扰研究的一项十分重要的进展。据中国科学院武汉病毒研究所专家介绍,RNA 干扰是生物体内普遍存在的一种古老的生物学现象,对控制生物体内基因表达起关键作用。而其作为人类中的一种重要抗病毒免疫机制,则是近年来由我国及欧美科学家的一系列研究共同发现。同时,RNA 干扰作为一...
3
2019 - 08 - 30
最近,《自然》杂志报道了不少关于癌症的研究。上周,学术经纬团队分享了一则癌症研究的重要突破——通过荧光标记,科学家们能够看清癌细胞如何“腐蚀”周边的健康细胞,发生转移。今天,我们又读到了一篇关于癌症转移的最新论文,它深刻揭示了癌症转移的复杂性,并提醒我们,在攻克癌症的道路上,我们还有很长的路要走……先来聊聊癌症。我们知道,癌症的发展就好像是一个熊孩子长大一样,会分成不同的阶段。在早期,癌细胞会疯狂生长,侵入和传播(invasion and dissemination)到组织内,在身体里形成肿瘤。到了晚期,癌细胞则会发生转移(metastasis),跑到身体的其他器官里落地生根,形成新的病灶。现在的医学知识告诉我们,一旦癌症发生了转移,患者的生命就岌岌可危。可是,癌细胞在一个地方长得好好的,它为啥会发生转移呢?过去的很多科学家相信,这与一种叫做E-cadherin(E-钙粘蛋白)的蛋白质有关。从功能上看,它负责把不同的细胞“粘”在一起。如果癌细胞能够减少这种钙粘蛋白的表达,就会变得更有“活动性”,也更容易发生转移。不过,科学家们也观察到了一些例外——在一种叫做“乳腺导管癌”的癌症中,发生转移的癌细胞,里头的E-钙粘蛋白含量可不少。这是为啥呢?有科学家解释说,这是因为癌细胞慢慢地又把自己“粘”回到了一起。这听起来是个合理的解释,但没有让所有人感到信服。为了寻找其他原因,来自美国知名的约...
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产品名称:

EVOS™ M7000 Imaging System

上市日期: 2019-04-15
产品类别: EVOS

规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


  • 产品描述
  • 产品功能
  • 产品参数

描述

The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-stacks in scan mode, and a superb optomechanical design enable the generation of publication-quality images and data with just a few clicks when and where needed.

The EVOS M7000 Imaging System offers these advantages:
• Outstanding image quality and versatility with a 5-position objective turret, 4-color LED fluorescence and transmitted light channels, and 3.2 MP CMOS color and B/W cameras
• Exceptional usability with fully automated X/Y scanning stage, autofocus, and acquisition routines
• High-speed image acquisition coupled with multi-position well scanning, and Z-stack and tile-stitch options lend power and flexibility to your data generation
• Fully integrated time-lapse live cell imaging using the optional EVOS Onstage Incubator for precise control of temperature, gases for normoxic or hypoxic conditions, and humidity
• Powerful image analysis capabilities for cell segmentation and quantification with the optional Celleste™ Image Analysis Software

Fully automated imaging system
The EVOS M7000 system combines and integrates precision components with a unique modern design functionality that enables high-quality automated fluorescence imaging anywhere with unprecedented workflow efficiency. Full automation of the precision X/Y-stage movement; changing of the 4 LED fluorescent light cubes, 5-position objective turret, focus, and exposure; and switching of the dual camera make the EVOS M7000 system an exceptional platform for a variety of demanding imaging applications. Through the intuitive acquisition interface, you can program the EVOS M7000 system to run well-plate scanning, time lapse experiments, and tile-stitch/montage area scans in Z-stack and/or time-lapse modes in your vessel of choice. For live cell imaging over multiple hours or days, the optional EVOS Onstage Incubator, which functions as an environmental chamber on top of the microscope stage, is operated seamlessly from within the instrument interface. The EVOS M7000 system is compatible with all accessories for the predecessor EVOS FL Auto imaging system.

Versatile and highly configurable
With a 5-position objective turret and the ability to simultaneous acquire images in four fluorescence channels plus transmitted light, the optical system can be easily configured to meet your needs. Choose from our broad range of high quality coverslip-corrected and long-working-distance objectives for use with plastic vessels or glass sides. Available from 1.25X to 100X magnification in achromat, fluorite, or apochromat models, together with over twenty LED light cubes, the sample imaging options are limitless. Dual monochrome and color high-sensitivity dual CMOS cameras enable seamless imaging of both fluorescent and chromogenically stained samples. Interchangeable vessel holders accommodate most vessel types and sizes, including slides, multi-well plates, culture flasks, and Petri dishes, and afford precise control and sample alignment by the automated stage. The vessel creation wizard in the user interface enables creation of profiles for custom sample vessels.

Powerful software
The EVOS M7000 software presents users with an extensive suite of tools for acquisition, visualization, and analysis. The user interface was designed with a strong emphasis on usability, including an option to view samples in a single field mode (Field View) or in a window that covers a much larger area (Area View). By using a zoom function, the Area View size can be adjusted. A user can explore a large sample area at low magnification, define regions of interest, and then seamlessly transition to the Scan function in Automate Mode and execute an area scan at higher magnification.

The enhanced power of the EVOS M7000 system enables more demanding automated acquisition routines like area scanning in time lapse and Z-stacks in scan mode to be performed. Visualization capabilities include multi-field image viewing gallery, mosaic tiling and tile stitching options, Z-stack visualization, and a video recording and movie maker/editor for time lapse sequences. The EVOS M7000 system is fully compatible with the EVOS Onstage Incubator environmental chamber for control of temperature, gases, and humidity. With the ability generate both hypoxic and normoxic conditions, it is possible to study live cells over extended periods with highly flexible time lapse automation routines.

For users needing more powerful image analysis capabilities, images acquired on the EVOS M7000 system can be analyzed directly using the optional Celleste Image Analysis Software. Celleste software offers powerful tools for image segmentation and classification that can be applied to a range of cell analysis applications for counting and measuring intensity, area, and shape changes over time, and more.

Smart LED illumination technology
All EVOS fluorescence imaging systems utilize our proprietary LED light cubes. This light engine outputs remarkable intensity over a short light path and delivers incomparable fluorophore excitation. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels to the sample and experimental conditions to minimize the risk of photo-toxicity and photo-bleaching in time-lapse studies. Hard-coated filters give sharper edges and significantly higher transmission efficiencies than traditional soft-coated filters.

Easy to use and reliable
The EVOS M7000 Imaging System is powerful, yet offers the simplicity of plug-and-play. Like other EVOS systems, it requires no warm-up or cool-down periods. The LED light source guarantees exceptional stability and durability, so you can turn the unit on and off whenever you need to image a sample. The environmentally safe, mercury-free LED bulbs are rated for >50,000 hours, compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. The long lifetime and low energy consumption translate into significantly lower operating costs compared to instruments with conventional light sources. The EVOS M7000 system is powered by an external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope. Whether acquiring single images or setting up automated routines, the EVOS M7000 system is remarkably easy to use and run. The 1920 x 1080 pixel resolution 23' LCD touch screen monitor enables “finger swipes” to expand or zoom in on images, and moving between microwell plate wells is done by a single touch. Operation is also also fully controllable via mouse.

The EVOS imaging systems are built from the ground up to maximize performance and optimize workflow. You will be astonished at how easy it is to operate and amazed at how extraordinary your images look on-screen.

Explore the entire EVOS line of imaging systems, accessories, and offers ›

System and hardware specifications
Optics: infinity‐corrected optical system; RMS‐threaded objectives with 45-mm parfocal distance
Imaging mode: fluorescence, brightfield, color brightfield, and phase contrast
Illumination: five position chamber for 4 fluorescence light cubes plus brightfield; light cubes with integrated hard coated filter set and LED light source with >50,000 hour life; broad selection of standard and specialty light cubes
Imaging methods: single color, multi-color, area scan with montage or tile-stitch, time lapse, Z-stacking, movie capture
Objective capacity: 5‐position turret
Objectives (not included): wide selection of high‐quality LWD and coverslip‐corrected objectives
Condenser: 60-mm long working distance condenser, 4 position turret with a clear aperture and 3 phase annuli
Stage: motorized X/Y scanning stage; travel range 120 mm x 80 mm with sub‐micron resolution, drop‐in inserts to receive vessel holders and lock down holders to fix sample in place during long scans
Focus mechanism: automated focus mechanism with sub‐micron resolution
LCD display: 23' high‐resolution touch screen color monitor (also fully controllable via mouse); 1920 x 1080 pixel resolution
Cameras: high-sensitivity 3.2 MP (2048 x 1536) monochrome CMOS sensor with 3.45 µm pixel resolution; high-sensitivity 3.2 MP (2048 x 1536) color CMOS sensor with 3.45 µm pixel resolution
Computer: external Dell PC with an Intel Core i7-8700 processor, 32 GB DDR4 RAM, 512 GB PCIe SSD, and NVIDIA Quadro P1000 with 4 GB discrete video graphics running Windows 10, designed to operate with touchscreen monitor and microscope
Captured images: 16‐bit RAW monochrome: TIFF, PNG; 8-bit: TIFF, PNG, JPG; movies and time‐lapse: AVI, WMV
Output ports: Computer: 1 x USB 3.1 Gen 2 Type-C; 5 x USB 3.1 Gen 1 Type-A; 4 x USB 2.0 Type-A; 1 Serial; 2 Display Ports 1.2; 1 RJ-45; 2 PS/2; 1 UAJ; 1 Line-out
Networking capability: connection through Windows/SMB network via an Ethernet cable connection
Power supply: 24 V AC adapter with country‐specific power cords
Dimensions (L x W x H): 18 x 14 x 13 inches (457 x 330 x 356 mm)
Weight: 16/35 (kg/lb)


规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


规格

Detection Method:Chromogenic, Fluorescent
Product Line:EVOS™
Product Size:1 system
Shipping Condition:Room Temperature


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