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1
2018 - 06 - 08
2018年6月6日讯 /生物谷BIOON /——PERIOD 2 (PER2)蛋白的多点磷酸化是决定哺乳动物生物钟周期的关键步骤。过去的研究认为PER2被酪蛋白激酶1(CK1)磷酸化的过程需要一种未被发现的蛋白激酶来启动,而CK1是一种从藻类到人类都高度保守的生物钟必需蛋白。这些磷酸化过程可以稳定PER2,延缓其降解以延长生物钟周期。图片来源:CCO public domain为了找到这个必需的蛋白质,一个由杜克-新加坡国立大学医学院研究人员领导的国际团队对小鼠PER2启动磷酸化的过程进行了综合的生物化学和生物物理学分析,结果惊讶地发现CK1δ/ε就是他们寻找的启动激酶。此外,他们还发现CK1ε和一个最近发现的CK1δ2剪接变体可以比CK1δ1更有效地启动磷酸化。尽管过去研究显示CK1对PER2的磷酸化对细胞环境很不敏感,但是研究人员通过使用生物节律磷酸化开关数学模型发现CK1羧基端尾部使得生物钟周期对细胞信号敏感。这些研究表明CK1羧基端是生物节律的一个重要的调节因子。(生物谷Bioon.com)参考资料:Rajesh Narasimamurthy et al, CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch, Proceedings of the National Academy of Sci...
2
2019 - 03 - 29
空气污染有关众所周知,污浊的空气对身体有害,每年在全球范围内造成数百万人死亡。这使空气污染成为比吸烟更厉害的杀手。然而,空气污染对人类大脑也有害吗?一项研究发现,在英国污染最严重地区,青少年的精神疾病问题(包括幻觉)更加常见。相关成果日前发表于《美国医学会杂志—精神病学》。然而,这种关联并非意味着吸入污浊空气会使青少年患上精神疾病,因为可能还有其他解释。该研究作者之一、伦敦国王学院的 Helen Fisher 表示,这项研究未显示出因果关系。Fisher 和同事发现,在 2000 名 18 岁青少年中,30% 的人报告称其在青少年时期至少有过一次精神疾病经历——其他针对年轻人的研究也报告了类似数字。然而研究发现,当把这些青少年的住址与空气污染情况作对照时,那些生活在污染程度较高地区的青少年更有可能有精神疾病史。在氮氧化物(由柴油车产生的污染物)含量最高的地区,每 20 名青少年中就有 12 名报告患有精神疾病;而在空气较清洁地区,降至每 20 人中有 7 人患病。目前尚不清楚空气污染与精神疾病存在何种关联。该团队提出的一种推测性机制是,污染物累积会直接影响大脑。研究表明,空气污染与额叶皮层和嗅球的炎症和退化有关,其中嗅球是大脑中负责嗅觉的部分。而大脑炎症已被证实与精神疾病有关。一个更简单的解释可能是,不是污染空气本身,而是汽车排放的噪音污染带来了问题。噪音污染会增加压力、扰乱睡眠,...
3
2019 - 08 - 01
第二看台老年性黄斑变性(AMD)、视网膜色素变性(RP)等视网膜变性疾病是目前尚无有效治疗手段的凶险致盲性眼病,也是公认的 “视力杀手”。由中南大学爱尔眼科学院院长唐仕波教授、爱尔眼科研究所副所长陈建苏教授带领团队,利用诱导多能干细胞(iPS)条件培养基和飞秒角膜透镜,联合构建高活性视网膜色素上皮细胞(RPE)的研究,不但有利于对视网膜色素上皮细胞生理特性、药物筛选等研究,还有利于构建组织工程视网膜层及其移植。这将帮助科学家开发出应用组织工程 RPE 细胞片治疗视网膜变性疾病和光感受器病变的新方法。培养高活性的视网膜细胞与年龄相关的老年性黄斑变性是发达国家 50 岁以上人群视力损害和致盲的首要病因,多达 90% 的病人无法治愈。数据显示,发达国家年龄 50 岁以上黄斑变性的发病率达 11%,目前我国的发病率接近发达国家,患病人数超过 3000 万人,并以每年 30 万人次的速度增加,成为我国现阶段 50 岁以上年龄群体发病率最高的三大眼科疾病之一,而且女性呈现出比男性更高的危险性。研究发现,未来最有希望治疗老年性黄斑变性的方式是视网膜色素上皮细胞疗法、视网膜黄斑部分的移植。那么,要采用 RPE 疗法,就需要先培养健康的视网膜细胞。陈建苏告诉科技日报记者,取出死亡时间在 3 小时内捐献者的带有部分脉络膜的视网膜组织,在解剖显微镜下可将带有部分脉络膜的 RPE 层从捐赠组织中分离出来,...
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总部地址:北京市海淀区西二旗西路热力公司院内泰禾文化园二层
产品名称:

EVOS™ FL Imaging System

上市日期: 2019-04-15
产品类别: EVOS

规格

Color:Transmitted Light
Data Output:BMP Files, JPG Files, PNG Files, TIFF Files
Detection Method:Fluorescent
Dimensions:36 cm (14 in) (W) x 58 cm (23 in) (H) x 47 cm (19 in) (D)
Display Interface:15-inch color monitor, Adjustable tilt
For Use With (Equipment):Fluorescence Microscope
Format:Specific Holder Attachments
Frequency:50⁄60 Hz
Input Voltage:100-240 VAC
Objectives:5 Objective Turret
Product Line:EVOS®
Product Size:1 each
Stage:Mechanical stage with X-Y axis fine-positioning controls
Weight:15.3 kg (33.7 lbs)


  • 产品描述
  • 产品功能
  • 产品参数

描述

The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.

The EVOS® FL Imaging System offers you these important advantages:

• Easy installation; no maintenance, assembly, alignment, or calibration
• For four-color fluorescence and transmitted light applications
• Five-position objective turret with front controls
• On-board software
• All-in-one design: digital camera, precision optics, LCD display, and USB storage

Fully Integrated Imaging System
The EVOS® FL system represents a new concept in transmitted light inverted microscopy. It is a fully integrated imaging system that combines precision optics, a 15' high-resolution LCD display, and a highly sensitive Sony ICX445 monochrome CCD camera (1280 x 960 pixel resolution, 1.3 Megapixels). Images are seamlessly acquired through the intuitive user interface using a mouse for easy control. Monochrome cameras are commonly used for high-performance fluorescence applications and provide the best sensitivity for detection of faint fluorescence signals. Color cameras, as on the EVOS® FL Color System, have lower fluorescence sensitivity but have the advantage of being able to differentiate structures by color in transmitted light (e.g., imaging stained tissue samples).

Compare cell imaging systems >

Versatile and Highly Configurable
The EVOS® FL system features an easily accessible 5-position objective turret and a 3-position condenser turret. The 4 fluorescence light cubes are lever-actioned for rapid and easy selection. The optical system can be configured to best meet your needs using our full range of high-quality objectives from 2x to 100x magnification. Lighting settings are automatically adjusted to match the objective magnification. The EVOS® FL system features a mechanical stage with X/Y-axis fine-positioning using control knobs conveniently located on the left side and the front of the stage. The stage accommodates EVOS® vessel holders that provide a perfect fit for most vessel types and sizes. Interchangeable stage plates accommodate most vessel types and sizes, including flasks, Petri dishes, multi-well plates, and slides.

Smart LED Illumination Technology
All EVOS® fluorescence imaging systems utilize our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light-path that delivers superior fluorophore excitation. Each light cube contains a precisely matched set of optical components to optimize the position, evenness, and intensity of the light beam. Digitally controlled LED light sources allow adjustment of illumination levels, dramatically improving control over photobleaching. Hard-coated filters give sharper edges and significantly higher transmission efficiencies than traditional soft-coated filters.

Integrated Software
The on-board computer makes the EVOS® FL system easy to run and use, and the intuitive, comprehensive software facilitates both image acquisition and analysis. Modules include time-lapse acquisition, manual-assist cell counting, and image review. Saved user settings work in conjunction with 'smart' controls to help increase efficiency and ease of use. Image data are saved to a USB flash drive for easy, portable data transfer or to a Windows-networked local server. Images can be saved in PNG, JPEG, BMP, and TIFF formats with a maximum captured image resolution of 1280 x 960 pixels.

These features make the EVOS® FL system ideal for both routine and demanding fluorescence imaging applications such as GFP-vector transfection efficiency analysis, routine cell and tissue culture, cell confluence determination, stem cell growth and differentiation, and developmental biology and tissue slice analyses. And the compact footprint makes it as easy to use the EVOS® FL system in a cell culture hood as on the bench.

Easy to Use and Reliable
The EVOS® FL Imaging System is plug-and-play. In addition to an exceptionally easy set-up and installation, it requires no warm-up or cool-down periods. The LED light source offers exceptional stability and durability—so you can turn the unit on and off whenever you need to image a sample. The environmentally safe mercury-free LED bulbs are rated for >50,000 hours (~17 years) of life, compared to 300 hours for a typical mercury bulb and 1,500 hours for a metal halide bulb. The long life and low energy consumption translate into significantly lower operating costs compared to instruments with conventional light sources. Finally, the advanced ergonomic design of the EVOS® systems removes the strain associated with conventional microscopes, enables shared viewing, and makes moving the units easy. For extended or precision use, the EVOS® arm rest provides comfortable support.

The EVOS® imaging systems are built from the ground up to maximize performance and optimize workflow. You will be astonished at how easy it is to operate and amazed at how extraordinary your images look on-screen.

Learn more about the EVOS® FL Imaging System
Explore the entire EVOS® line of imaging systems and accessories

System Highlights
Optics: infinity-corrected optical system, RMS-threaded objectives with 45 mm parfocal distance
Illumination: adjustable intensity LED (>50,000-hour life per light cube)
Light cubes (not included): broad selection of patented standard and specialty light cubes
Common light cubes include: DAPI (Ex 360 nm/Em 447 nm), GFP (Ex 470 nm/Em 525 nm), RFP (Ex 530 nm/Em 593 nm), Texas Red® (Ex 585 nm/Em 624), Cy5 (Ex 628 nm/Em 692 nm)
Contrast methods: fluorescence and transmitted light (brightfield & phase contrast)
Objective turret: 5-position, front-mounted control
Objectives (not included): wide selection of high-quality LWD and coverslip-corrected objectives available
Condenser: 3-position turret with brightfield and phase contrast annuli
Condenser working distance: 60 mm
Stage: mechanical 'glide' stage; X-Y axis fine-positioning controls: 28.3 mm (1.11') per rotation, 110 mm x 110 mm (4.3' x 4.3') range of motion; Z-axis focusing controls: 480 µm/rotation; interchangeable vessel holders are available for most common shapes and sizes
Focus mechanism: coaxial focus knobs with tension control
Course focus: 38 mm/rev
Fine focus: 0.2mm/rev, precision 0.002 mm
LCD display: 15-inch color, 1024 x 768 pixels, adjustable tilt
Camera: Sony ICX445 monochrome CCD, 1/3' 1280 x 960 pixels, 1.3 Megapixels
Image acquisition: onboard microprocessor, built-in software for image acquisition via mouse control
Captured images: 16-bit monochrome TIFF or PNG (12-bit dynamic range); 24-bit color TIFF or PNG; jpeg, bmp, 1280 x 960 pixels
Output ports: 3 USB and 1 DVI
Power supply: AC adapter with country-specific power cords; input 100-240 V, 50-60 Hz; output 12 VDC/4.15 A
Dimensions: operating height = 57.8 cm (22.75 in); storage/transport height = 32.4 cm (12.75 in); depth = 47.0 cm (18.5 in); width = 35.5 cm (14.0 in)
Weight: 15.3 kg (33.7 lbs) 


规格

Color:Transmitted Light
Data Output:BMP Files, JPG Files, PNG Files, TIFF Files
Detection Method:Fluorescent
Dimensions:36 cm (14 in) (W) x 58 cm (23 in) (H) x 47 cm (19 in) (D)
Display Interface:15-inch color monitor, Adjustable tilt
For Use With (Equipment):Fluorescence Microscope
Format:Specific Holder Attachments
Frequency:50⁄60 Hz
Input Voltage:100-240 VAC
Objectives:5 Objective Turret
Product Line:EVOS®
Product Size:1 each
Stage:Mechanical stage with X-Y axis fine-positioning controls
Weight:15.3 kg (33.7 lbs)


规格

Color:Transmitted Light
Data Output:BMP Files, JPG Files, PNG Files, TIFF Files
Detection Method:Fluorescent
Dimensions:36 cm (14 in) (W) x 58 cm (23 in) (H) x 47 cm (19 in) (D)
Display Interface:15-inch color monitor, Adjustable tilt
For Use With (Equipment):Fluorescence Microscope
Format:Specific Holder Attachments
Frequency:50⁄60 Hz
Input Voltage:100-240 VAC
Objectives:5 Objective Turret
Product Line:EVOS®
Product Size:1 each
Stage:Mechanical stage with X-Y axis fine-positioning controls
Weight:15.3 kg (33.7 lbs)


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