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3个妙招保你免疫健康，远离新冠病毒!
3个妙招保你免疫健康，远离新冠病毒!
2020 - 04 - 23
2020年4月20日讯 /生物谷BIOON /——无论是在杂货店擦擦购物车后至少洗手20秒，还是尽可能呆在家里，我们都在适应一种新常态，以限制感染SARS-CoV-2。现在也是关注我们的免疫系统的好时机，如果我们暴露在疾病中，免疫系统会影响我们身体的反应。它受到我们日常习惯的深刻影响。科罗拉多大学博尔德分校生态与进化生物学的杰出教授、该系荣誉项目的联合主任Barbara Demmig-Adams说：'小事情也能带来改变。'Demmig-Adams研究的是植物抗氧化剂，它是我们饮食的重要组成部分，因为人体自身无法产生这些营养物质。她还教授一门关于生活方式医学的本科课程，以便将植物对人类生活的重要性转化为与学生相关的研究。图片来源：https://cn.bing.com通过她自己的研究和教学，Demmig-Adams发现人类免疫系统的力量被现代生活的许多方面削弱了。我们坐得太多，吃能量丰富的食物，缺乏微量营养素，还要应对长期的心理压力和睡眠不足。但是一个人可以采取一些措施来改善他们的免疫健康。限制和管理压力，获得更多的休息睡眠，不仅可以提高免疫力，还可以帮助对抗焦虑、抑郁和其他许多疾病和失调。这些措施，加上均衡的饮食，也支持着人体的微生物群落，这些有益的微生物位于我们的外表面和内表面。Demmig-Adams说，这些微生物不仅提供了抵御感染入侵者的第一道防线，而且还产生...
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一次编辑数百种基因！遗传学大牛George Church发布基因编辑新方法
一次编辑数百种基因！遗传学大牛George Church发布基因编辑新方法
2018 - 05 - 25
基因编辑技术帮助人们实现了“编辑生命”的愿望，但该技术自身存在的局限性也限制了其广泛应用，此前人们的研究热情也多集中在编辑的效率、准确性与安全性，但常规的基因编辑技术在一个反应中仅能对一个或数个基因进行操作，且通常会在基因组中留下额外的不需要的序列修改，在大型研究中，已有的基因编辑技术远远无法满足大量不同基因的编辑需求。为解决上述问题，哈佛大学George Church教授领导的研究团队开发了一种基于CRISPR-Cas9的新型高通量基因编辑方法：guide+donor，该方法可以在单个酿酒酵母中同时精确改变数百个不同基因，编辑效率达到80％至100％，还能在生物体内选择特定行为细胞，进行定向基因编辑和修复。guide+donor除帮助构建大型文库外，还能进行基因功能分析，发现一些未知的基因突变和功能。5月21日，相关研究成果发表在著名学术期刊Nature Biotechnology上，文章题为“High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast”。George Church教授人类的基因变异通常是点突变导致，为在不干扰其他潜在变异的情况下重构酿酒酵母中的某些变异，CRISPR-Cas9技术借助sgRNA精确靶向D...
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揭秘细菌挑食之谜
揭秘细菌挑食之谜
2019 - 03 - 22
给你一个冰淇淋和一块蛋糕，你先吃哪个？一块面包和一个牛油果呢？两个一块吃吗？1941 年微生物学家 Jacques Monod 给细菌提出了同样的问题。他给大肠杆菌同时提供两种食物（碳源），结果看到了两类不同的现象：对某一些食物组合（比麦芽糖和苹果酸），细菌两种同时吃，而对另一些组合（比如葡萄糖和乳糖），细菌要先吃完一种（葡萄糖），然后再会去吃另一种（乳糖）。随后 Monod 和 François Jacob 一道，找出了细菌在有葡萄糖和乳糖的情况下只吃葡萄糖的分子机制—乳糖操纵子：在这两种糖都存在的时候，细胞不会去表达运输和消化乳糖的相关基因，并获得了 1965 年的诺贝尔生理学奖。可是为什么细菌要挑食呢？为什么对于有些食物的组合它们又不挑呢？北京大学汤超教授团队发现细菌的这一套进食策略能够使它们最优化的生长。如果哪个菌种想任性一把，同时吃葡萄糖和乳糖，或者对麦芽糖和苹果酸挑食，那么它们的代价就是生长速率的降低，进而面临被淘汰的危险。结合代谢网络的拓扑特征和细胞内蛋白资源的优化分配，研究团队的理论模型定量的解释了细菌面对多种碳源的进食策略。在两类碳源同时被细菌消耗的情况下，模型预测并用实验验证了细菌内不同氨基酸上的碳原子来自两种碳源的比例。这个例子进一步说明了在看似复杂的生命现象中，存在简洁的原理与定量的规律。相关文章发表在《自然 - 通讯》杂志上。北京大学定量生物学中...
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EVOS™ Vessel Holder, universal
产品名称： EVOS™ Vessel Holder, universal
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder has a 25.4 mm opening and accommodates most vessel types. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samp...
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EVOS™ Vessel Holder, Greiner T-75 flask
产品名称： EVOS™ Vessel Holder, Greiner T-75 flask
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
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EVOS™ Vessel Holder, Hemocytometer
产品名称： EVOS™ Vessel Holder, Hemocytometer
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates a hemocytometer. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel hol...
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EVOS™ Vessel Holder, Nunc™ T-75 flask
产品名称： EVOS™ Vessel Holder, Nunc™ T-75 flask
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Nunc® T-75 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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EVOS™ Vessel Holder, two 25-cm T-flasks
产品名称： EVOS™ Vessel Holder, two 25-cm T-flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 cm T-flasks. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vessel ...
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EVOS™ Vessel Holder, one 100-mm Petri dish
产品名称： EVOS™ Vessel Holder, one 100-mm Petri dish
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one 100 mm Petri dish. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ Vessel Holder, two 60-mm Petri dishes
产品名称： EVOS™ Vessel Holder, two 60-mm Petri dishes
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 60 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ves...
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EVOS™ Vessel Holder, four 35-mm Petri dishes
产品名称： EVOS™ Vessel Holder, four 35-mm Petri dishes
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates four 35 mm Petri dishes. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ve...
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EVOS™ Vessel Holder, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 12
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates two 25 x 75 mm slides. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of vess...
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EVOS™ 4X Objective, fluorite, LWD, phase-contrast
产品名称： EVOS™ 4X Objective, fluorite, LWD, phase-contrast
型号：
时间： 2019 - 04 - 12
描述This fluorite objective is ideal for fluorescence and demanding transmitted-light applications. This is a long working distance (LWD) objective that is optimized for the imaging of slides, cell culture dishes and flasks, and microtiter plates. This is also a phase-contrast objective, making it useful for hard-to-see, translucent speciments. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies nee...
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EVOS™ Light Cube, Cy™5
产品名称： EVOS™ Light Cube, Cy™5
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The Cy®5 light cube is ideal for use with Alexa Fluor&...
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EVOS™ Light Cube, RFP
产品名称： EVOS™ Light Cube, RFP
型号：
时间： 2019 - 04 - 12
描述All EVOS® fluorescence imaging systems and the Countess® II FL Automated Cell Counter contain our unique, proprietary LED light cubes. This world-leading light engine outputs remarkable intensity over a short light path that delivers superior fluorophore excitation. Each cube contains an LED, condensing optics, and hard-coated filters. EVOS® light cubes are user-changeable and automatically recognized by the system. The RFP light cube is ideal for use with Alexa Fluor® ...
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