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冠状病毒简史：带你了解冠状病毒的前世今生！
冠状病毒简史：带你了解冠状病毒的前世今生！
2020 - 04 - 30
2020年4月28日讯 /生物谷BIOON /——我们大多数人一生中至少会感染一次冠状病毒。对于许多人来说，这可能是一个令人担忧的事实，尤其是那些只听说过一种冠状病毒SARS-CoV-2的人。冠状病毒远远不止SARS-CoV-2这一种。冠状病毒实际上是数百种病毒的一个家族。其中大多数感染动物，如蝙蝠、鸡、骆驼和猫。有时，感染一个物种的病毒会发生变异，从而开始感染另一个物种。这被称为'跨物种传播'或'溢出效应'。第一种冠状病毒是在20世纪30年代的鸡身上发现的。直到20世纪60年代首次发现人类冠状病毒，人类才花了几十年的时间。迄今为止，有7种冠状病毒有能力导致人类患病。四种是地方性的(通常在特定人群或某个地区发现)，通常引起轻微的疾病，但三种可能引起严重得多甚至致命的疾病。图片来源：https://cn.bing.com普通感冒冠状病毒在世界各地都有，大约有10-15%的普通感冒是由冠状病毒引起的，大部分发生在冬季。导致人类轻度至中度疾病的冠状病毒称为：229E、OC43、NL63和HKU1。首次发现能够感染人类的冠状病毒是229E和OC43。这两种病毒通常会导致普通的感冒，很少会导致严重的疾病。它们通常与其他呼吸道感染同时被发现。当在病人体内发现多种病毒或病毒和细菌时，这就称为合并感染，并可导致更严重的疾病。2004年，荷兰首次在患有细支气管炎(一种...
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PNAS：重大发现！科学家发现生物钟的关键开关
PNAS：重大发现！科学家发现生物钟的关键开关
2018 - 06 - 08
2018年6月6日讯 /生物谷BIOON /——PERIOD 2 (PER2)蛋白的多点磷酸化是决定哺乳动物生物钟周期的关键步骤。过去的研究认为PER2被酪蛋白激酶1（CK1）磷酸化的过程需要一种未被发现的蛋白激酶来启动，而CK1是一种从藻类到人类都高度保守的生物钟必需蛋白。这些磷酸化过程可以稳定PER2，延缓其降解以延长生物钟周期。图片来源：CCO public domain为了找到这个必需的蛋白质，一个由杜克-新加坡国立大学医学院研究人员领导的国际团队对小鼠PER2启动磷酸化的过程进行了综合的生物化学和生物物理学分析，结果惊讶地发现CK1δ/ε就是他们寻找的启动激酶。此外，他们还发现CK1ε和一个最近发现的CK1δ2剪接变体可以比CK1δ1更有效地启动磷酸化。尽管过去研究显示CK1对PER2的磷酸化对细胞环境很不敏感，但是研究人员通过使用生物节律磷酸化开关数学模型发现CK1羧基端尾部使得生物钟周期对细胞信号敏感。这些研究表明CK1羧基端是生物节律的一个重要的调节因子。（生物谷Bioon.com）参考资料：Rajesh Narasimamurthy et al, CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch, Proceedings of the National Academy of Sci...
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精神病或与空气污染有关
精神病或与空气污染有关
2019 - 03 - 29
空气污染有关众所周知，污浊的空气对身体有害，每年在全球范围内造成数百万人死亡。这使空气污染成为比吸烟更厉害的杀手。然而，空气污染对人类大脑也有害吗？一项研究发现，在英国污染最严重地区，青少年的精神疾病问题（包括幻觉）更加常见。相关成果日前发表于《美国医学会杂志—精神病学》。然而，这种关联并非意味着吸入污浊空气会使青少年患上精神疾病，因为可能还有其他解释。该研究作者之一、伦敦国王学院的 Helen Fisher 表示，这项研究未显示出因果关系。Fisher 和同事发现，在 2000 名 18 岁青少年中，30% 的人报告称其在青少年时期至少有过一次精神疾病经历——其他针对年轻人的研究也报告了类似数字。然而研究发现，当把这些青少年的住址与空气污染情况作对照时，那些生活在污染程度较高地区的青少年更有可能有精神疾病史。在氮氧化物（由柴油车产生的污染物）含量最高的地区，每 20 名青少年中就有 12 名报告患有精神疾病；而在空气较清洁地区，降至每 20 人中有 7 人患病。目前尚不清楚空气污染与精神疾病存在何种关联。该团队提出的一种推测性机制是，污染物累积会直接影响大脑。研究表明，空气污染与额叶皮层和嗅球的炎症和退化有关，其中嗅球是大脑中负责嗅觉的部分。而大脑炎症已被证实与精神疾病有关。一个更简单的解释可能是，不是污染空气本身，而是汽车排放的噪音污染带来了问题。噪音污染会增加压力、扰乱睡眠，...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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7-AAD (7-Aminoactinomycin D)
产品名称： 7-AAD (7-Aminoactinomycin D)
型号：
时间： 2019 - 04 - 17
描述7-aminoactinomycin D (7-AAD) is a fluorescent intercalator that undergoes a spectral shift upon association with DNA. 7-AAD/DNA complexes can be excited by the 488 nm laser and has an emission maxima of 647 nm, making this nucleic acid stain useful for multicolor fluorescence microscopy and flow cytometry. 7-AAD appears to be generally excluded from live cells, but can be used with cells that have been fixed and permeabilized. 7-AAD has been used for cell cycle analysis by flow cytometry....
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Dynabeads™ CD45
产品名称： Dynabeads™ CD45
型号：
时间： 2019 - 04 - 17
DescriptionDynabeads® CD45 are superparamagnetic beads covalently coupled to anti-human CD45 antibody that enable isolation or depletion of CD45+ leucocytes directly from whole blood, buffy coat, or MNC suspensions. Dynabeads® CD45 can also be used to enrich epithelial tumor cells. The CD45 antigen is weakly expressed on myeloid cells. To efficiently deplete or isolate all leucocytes including myeloid cells, use Dynabeads® CD15 (Cat. No. 11137D) in combination with Dynabeads®...
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EVOS™ 50X Oil Objective, achromat, coverslip-corrected
产品名称： EVOS™ 50X Oil Objective, achromat, coverslip-corrected
型号：
时间： 2019 - 04 - 15
描述This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.Additional characteristics of this EVOS® objective:• Magnification: 50X• Numerical Aperture: 0.95• Working Distance:...
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EVOS™ M7000 Imaging System
产品名称： EVOS™ M7000 Imaging System
型号：
时间： 2019 - 04 - 15
描述The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-sta...
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EVOS™ FL Imaging System
产品名称： EVOS™ FL Imaging System
型号：
时间： 2019 - 04 - 15
描述The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.The EVOS® FL Imaging System offers you these important ad...
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EVOS™ Onstage Master Plate
产品名称： EVOS™ Onstage Master Plate
型号：
时间： 2019 - 04 - 15
描述The EVOS® Onstage Master Plate is part of the EVOS® Onstage Incubator and holds the EVOS® Onstage Vessel Holder. The EVOS® Onstage Incubator is an environmental chamber designed specifically for use with the EVOS® FL Auto Imaging System. This master plate plus vessel holder design, with vessel holders available that accommodate various types of cell culture vessels, provides flexibility in your approach to extended time-lapse imaging experiments under precisely co...
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EVOS™ Onstage Vessel Holder, two 25-mL flasks
产品名称： EVOS™ Onstage Vessel Holder, two 25-mL flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates two 25-mL T-flasks. With ...
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EVOS™ Onstage Vessel Holder, multi-well plates
产品名称： EVOS™ Onstage Vessel Holder, multi-well plates
型号：
时间： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates multi-well plates (dimensi...
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EVOS™ Vessel Holder for Automated Stage, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder for Automated Stage, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder securely holds two 25 x 75 mm standard or chamber microscope slides and is specific for the automated stage of the EVOS® FL Auto Imaging System. It is just one of many easy-to-change vessel holders and stage plates available for this instrument plat...
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EVOS™Vessel Holder, Greiner/BD T-25 flask
产品名称： EVOS™Vessel Holder, Greiner/BD T-25 flask
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner/BD T-25 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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