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J Appl Physiol：中年时期的有氧运动或能预防多种与年龄相关的慢性疾病
J Appl Physiol：中年时期的有氧运动或能预防多种与年龄相关的慢性疾病
2021 - 11 - 06
来自美国和日本的科学家们通过研究发现，由于进行了有规律的有氧运动，相比年轻成年人而言，中年的耐力运动员还会显示出相当水平的上述因素。本文研究结果提供了强有力的迹象表明，血压的控制和血管弹性程度的改善或有助于更好地改善中年人群大脑血流的调节。2021年12月19日 讯 /生物谷BIOON/ --中年有氧运动或能显著影响年龄相关的大脑和心血管调节的变化，中年耐力运动员要比相同年龄组的久坐成年人有着更好的血压控制和更高的动脉弹性（一种心血管疾病风险的无创测量）。近日，一篇发表在国际杂志Journal of applied Physiology上题为“Midlife aerobic exercise and dynamic cerebral autoregulation： associations with baroreflex sensitivity and central arterial stiffness”的研究报告中，来自美国和日本的科学家们通过研究发现，由于进行了有规律的有氧运动，相比年轻成年人而言，中年的耐力运动员还会显示出相当水平的上述因素。本文研究结果提供了强有力的迹象表明，血压的控制和血管弹性程度的改善或有助于更好地改善中年人群大脑血流的调节。图片来源：Pixabay/CC0 Public Domain中年机体动脉的僵硬程度与晚年中风和痴呆症风险增加有关，同时还会增加机...
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Nature：挑战常规！揭示一些乳腺癌和卵巢癌对PARP抑制剂产生耐药性的新机制
Nature：挑战常规！揭示一些乳腺癌和卵巢癌对PARP抑制剂产生耐药性的新机制
2018 - 07 - 20
一种非常复杂的治疗一些乳腺癌和卵巢癌的方法就是使用一类叫做PARP抑制剂的药物。PARP抑制剂旨在利用让发生某些突变的肿瘤特别致命的缺陷。然而，这种靶向癌症治疗方法有时会失败，科学家们迫切地想要知道其中的原因。 如今，在一项新的研究中，美国洛克菲勒大学的Titia de Lange教授及其团队对这种耐药性机制提供了新的认识，并且为抵抗这种耐药性提供了新的希望。他们发现了由基因BRCA1发生的错误引发的一些癌症逃避旨在杀死它们的定制药物的分子机制。这一发现也挑战了之前针对这些PARP抑制剂成功地或未能给患者带来益处的机制作出的猜测。相关研究结果于2018年7月18日在线发表在Nature期刊上，论文标题为“53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in”。图片来自Laboratory of Cell Biology and Genetics at The Rockefeller University。他们的发现有助于解释为什么某些癌症会对PARP抑制剂作出反应，而其他癌症却没有---这种认识最终可能有助于改善对患者的治疗。 缺陷和机会 专家们预测今年将有大约288000例乳腺癌和卵巢癌新确诊病例。这些癌症的很大一部分是由人类基因组中的两个最臭名昭着的基因--- ...
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Sci Rep： 抑制蛋白质磷酸化制促进损伤后的视神经再生
Sci Rep： 抑制蛋白质磷酸化制促进损伤后的视神经再生
2019 - 05 - 23
2019年5月22日 讯 /生物谷BIOON/ --早稻田大学Toshio Ohshima教授的一项新研究发现，抑制塌陷反应介质蛋白2（CRMP2）（一种微管结合蛋白）的磷酸化可以抑制神经纤维的退化，促进视神经损伤后的再生。最近在《Scientific Reports》杂志上发表的这项研究结果可以为视神经病变患者开发新型治疗方法。青光眼患者视野中会出现盲点，并且当视神经恶化时可能导致失明。神经纤维的这种恶化和功能丧失也发生在创伤性神经损伤和神经系统疾病，例如阿尔茨海默病和ALS中。目前，由于轴突再生受到抑制因子的限制，因此不存在在损伤或变性后完全修复视网膜，脊髓和中枢神经系统的其他部分的方法。（图片来源：Www.pixabay.com）在过去的研究中，已经发现了抑制轴突再生的潜在机制，并且认为解决这些机制可以使科学家们在开发新的中枢神经系统损伤治疗方法方面更进一步。CRMP2蛋白质分子起到稳定微管的作用，微管在神经元细胞水平为中枢神经系统提供结构支持，并通过与微管蛋白二聚体结合促进聚合。然而，这些功能通过磷酸化（一种调节神经元蛋白的机制）被各种激酶阻止。“在我们之前的研究中，我们所做的是开发CRMP2敲入小鼠并从基因上抑制其CRMP2磷酸化，”Ohshima教授解释说。 “结果，CRMP2敲入小鼠在脊髓损伤后表现出轴突再生的促进。由此，我们假设在视神经损伤后也可以观察到相同的现象。...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
产品名称： Attune™ NxT Acoustic Focusing Cytometer, blue/red/violet/yellow
型号：
时间： 2019 - 04 - 17
描述The 2018 Attune NxT Acoustic Focusing Cytometer has expanded functionalities to drive your research forward. Designed and developed to remove common barriers associated with flow cytometry, the evolutionary capabilities of the Attune NxT flow cytometer offer adaptable optical configuration options so you can get the most out of your multicolor analysis.• Free Attune NxT software with researcher-inspired upgrades• New green laser option for expanded utility and fluorochrome options• Simple push...
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7-AAD (7-Aminoactinomycin D)
产品名称： 7-AAD (7-Aminoactinomycin D)
型号：
时间： 2019 - 04 - 17
描述7-aminoactinomycin D (7-AAD) is a fluorescent intercalator that undergoes a spectral shift upon association with DNA. 7-AAD/DNA complexes can be excited by the 488 nm laser and has an emission maxima of 647 nm, making this nucleic acid stain useful for multicolor fluorescence microscopy and flow cytometry. 7-AAD appears to be generally excluded from live cells, but can be used with cells that have been fixed and permeabilized. 7-AAD has been used for cell cycle analysis by flow cytometry....
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Dynabeads™ CD45
产品名称： Dynabeads™ CD45
型号：
时间： 2019 - 04 - 17
DescriptionDynabeads® CD45 are superparamagnetic beads covalently coupled to anti-human CD45 antibody that enable isolation or depletion of CD45+ leucocytes directly from whole blood, buffy coat, or MNC suspensions. Dynabeads® CD45 can also be used to enrich epithelial tumor cells. The CD45 antigen is weakly expressed on myeloid cells. To efficiently deplete or isolate all leucocytes including myeloid cells, use Dynabeads® CD15 (Cat. No. 11137D) in combination with Dynabeads®...
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EVOS™ 50X Oil Objective, achromat, coverslip-corrected
产品名称： EVOS™ 50X Oil Objective, achromat, coverslip-corrected
型号：
时间： 2019 - 04 - 15
描述This achromat objective is ideal for general applications. This is a coverslip-corrected objective that is optimized for imaging through #1.5 coverslips. All EVOS® objectives offer outstanding optical performance from visible light to near infrared light. The extensive choice of objectives satisfies needs across the spectrum of magnifications and optical specifications.Additional characteristics of this EVOS® objective:• Magnification: 50X• Numerical Aperture: 0.95• Working Distance:...
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EVOS™ M7000 Imaging System
产品名称： EVOS™ M7000 Imaging System
型号：
时间： 2019 - 04 - 15
描述The EVOS M7000 Imaging System is a high-performance, fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. It was developed to meet today’s expectations for image quality, user interface interactions, data generation speed and flexibility, and end-user value. The powerful and time-saving acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-sta...
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EVOS™ FL Imaging System
产品名称： EVOS™ FL Imaging System
型号：
时间： 2019 - 04 - 15
描述The EVOS® FL Imaging System is a fully integrated, digital, inverted imaging system for four-color fluorescence and transmitted-light applications. It is powerful, yet easy-to-use and delivers high-definition images with exceptional convenience. The unique light cubes, sensitive camera, and precision-engineered optical system make the EVOS® FL system ideal for both demanding and routine fluorescence imaging applications.The EVOS® FL Imaging System offers you these important ad...
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EVOS™ Onstage Master Plate
产品名称： EVOS™ Onstage Master Plate
型号：
时间： 2019 - 04 - 15
描述The EVOS® Onstage Master Plate is part of the EVOS® Onstage Incubator and holds the EVOS® Onstage Vessel Holder. The EVOS® Onstage Incubator is an environmental chamber designed specifically for use with the EVOS® FL Auto Imaging System. This master plate plus vessel holder design, with vessel holders available that accommodate various types of cell culture vessels, provides flexibility in your approach to extended time-lapse imaging experiments under precisely co...
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EVOS™ Onstage Vessel Holder, two 25-mL flasks
产品名称： EVOS™ Onstage Vessel Holder, two 25-mL flasks
型号：
时间： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates two 25-mL T-flasks. With ...
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EVOS™ Onstage Vessel Holder, multi-well plates
产品名称： EVOS™ Onstage Vessel Holder, multi-well plates
型号：
时间： 2019 - 04 - 15
描述EVOS® Onstage vessel holders maximize your choice of cell culture vessels when conducting time-lapse imaging experiments using the EVOS® FL Auto Imaging System equipped with an EVOS® Onstage Incubator. EVOS® Onstage vessel holders allow a perfect fit of your micro-well plates or cell culture flasks/dishes to the master plate of the EVOS® Onstage Incubator for increased precision in sample alignment. This particular vessel holder accommodates multi-well plates (dimensi...
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EVOS™ Vessel Holder for Automated Stage, two 25 x 75 mm slides
产品名称： EVOS™ Vessel Holder for Automated Stage, two 25 x 75 mm slides
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder securely holds two 25 x 75 mm standard or chamber microscope slides and is specific for the automated stage of the EVOS® FL Auto Imaging System. It is just one of many easy-to-change vessel holders and stage plates available for this instrument plat...
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EVOS™Vessel Holder, Greiner/BD T-25 flask
产品名称： EVOS™Vessel Holder, Greiner/BD T-25 flask
型号：
时间： 2019 - 04 - 15
描述EVOS® vessel holders allow a perfect fit of your microscope slide, cell culture flask or dish, or micro-well plate to the stage of the EVOS® imaging systems for increased precision in sample alignment. This particular vessel holder accommodates one Greiner/BD T-25 flask. It is just one of many easy-to-change vessel holders and stage plates available for this instrument platform. With a snug and secure fit, yet readily switched, these accessories make imaging samples in a range of ...
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